Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic
stresses, are our bodies' greatest weapons to battle against cancer onset and development …

Since the discovery of the first MDM2 inhibitors, we have gained deeper insights into the
cellular roles of MDM2 and p53. In this review, we focus on MDM2 inhibitors that bind to the …

Glioblastoma contains a rare population of self-renewing brain tumor stem cells (BTSCs)
which are endowed with properties to proliferate, spur the growth of new tumors, and at the …

Aims/hypothesis Diabetic cardiomyopathy, characterised by increased oxidative damage
and mitochondrial dysfunction, contributes to the increased risk of heart failure in individuals …

Mitochondria are essential organelles in balancing oxidative stress and cell death during
cancer cell proliferation. Rapid tumor growth induces tremendous stress on mitochondria …

Several classes of antibiotics have long been known to have beneficial effects that cannot
be explained strictly on the basis of their capacity to control the infectious agent. Here, we …

Myocardial infarction (MI) is the leading cause of premature death among adults.
Cardiomyocyte death and dysfunction of the remaining viable cardiomyocytes are the main …

Since its discovery over 35 years ago, MDM2 has emerged as an attractive target for the
development of cancer therapy. MDM2's activities extend from carcinogenesis to immunity to …

Simple Summary The p53 pathway is a major tumor suppressor pathway that prevents the
propagation of abnormal cells by regulating DNA repair, cell cycle progression, cell death, or …

During pregnancy, the human body is quite vulnerable to external stimuli. Zinc oxide
nanoparticles (ZnO-NPs) are widely used in daily life, and they enter the human body via …