Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

In physiological conditions, adult neurons have low intracellular Cl−[(Cl−) I] levels
underlying the γ-aminobutyric acid (GABA) ergic inhibitory drive. In contrast, neurons have …

Down syndrome (DS) is the most frequent genetic cause of intellectual disability, and altered
GABAergic transmission through Cl−-permeable GABAA receptors (GABAARs) contributes …

Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the
foundation of nervous system function. This inhibition is largely mediated by the …

Background Preclinical data suggest that the loop-diuretic bumetanide might be an effective
treatment for neonatal seizures. We aimed to assess dose and feasibility of intravenous …

Abstract The Na–K–2Cl cotransporter NKCC1 and the neuron-specific K–Cl cotransporter
KCC2 are considered attractive CNS drug targets because altered neuronal chloride …

The inhibitory neurotransmitter γ-aminobutyric acid (GABA) plays an important role in the
modulation of neuronal excitability, and a disruption of GABAergic transmission contributes …

As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid
(GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride …

The epilepsies are common neurologic disorders characterized by spontaneous recurrent
seizures. Boys, girls, men, and women of all ages are affected by epilepsy and, in many …

Objective In the absence of controlled trials, treatment of neonatal seizures has changed
minimally despite poor drug efficacy. We tested bumetanide added to phenobarbital to treat …