The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

The synthesis of vitellogenin and its uptake by maturing oocytes during egg maturation are
essential for successful female reproduction. These events are regulated by the juvenile …

Social bees harbor a simple and specialized microbiota that is spatially organized into
different gut compartments. Recent results on the potential involvement of bee gut …

Ticks transmit more pathogens to humans and animals than any other arthropod. We
describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors …

Immune defense and reproduction are physiologically and energetically demanding
processes and have been observed to trade off in a diversity of female insects. Increased …

In Drosophila, the fat body (FB), a functional analog of the vertebrate adipose tissue, is the
nutrient sensor that conveys the nutrient status to the insulin-producing cells (IPCs) in the fly …

Multicellular animals match costly activities, such as growth and reproduction, to the
environment through nutrient-sensing pathways. The insulin/IGF signaling (IIS) pathway …

Many male animals wield ornaments or weapons of exaggerated proportions. We propose
that increased cellular sensitivity to signaling through the insulin/insulin-like growth factor …

Managing metabolic resources is critical for insects during diapause when food sources are
limited or unavailable. Insects accumulate reserves prior to diapause, and metabolic …

Insects in diapause characteristically feed very little or not at all, thus they are largely or
totally dependent on energy reserves sequestered prior to the entry into diapause. Fats are …