High density lipoproteins: metabolism, function, and therapeutic potential

A Jomard, E Osto - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
High Density Lipoproteins (HDLs) have long been considered as “good cholesterol,”
beneficial to the whole body and, in particular, to cardio-vascular health. However, HDLs are …

Coagulatory defects in type-1 and type-2 diabetes

AIS Sobczak, AJ Stewart - International journal of molecular sciences, 2019 - mdpi.com
Diabetes (both type-1 and type-2) affects millions of individuals worldwide. A major cause of
death for individuals with diabetes is cardiovascular diseases, in part since both types of …

[HTML][HTML] Lipidome as a predictive tool in progression to type 2 diabetes in Finnish men

T Suvitaival, I Bondia-Pons, L Yetukuri, P Pöhö… - Metabolism, 2018 - Elsevier
Background There is a need for early markers to track and predict the development of type 2
diabetes mellitus (T2DM) from the state of normal glucose tolerance through prediabetes. In …

High-density lipoprotein (HDL) triglyceride and oxidized HDL: new lipid biomarkers of lipoprotein-related atherosclerotic cardiovascular disease

F Ito, T Ito - Antioxidants, 2020 - mdpi.com
Lipid markers are well-established predictors of vascular disease. The most frequently
measured lipid markers are total cholesterol, high-density lipoprotein (HDL)-cholesterol …

HDL triglycerides: a new marker of metabolic and cardiovascular risk

J Girona, N Amigó, D Ibarretxe, N Plana… - International Journal of …, 2019 - mdpi.com
While cholesterol content in high-density lipoproteins (HDLs) is a well-established inverse
marker of cardiovascular risk, the importance of HDL–triglyceride (HDL-TG) concentration is …

HDL functionality in reverse cholesterol transport—Challenges in translating data emerging from mouse models to human disease

M Lee-Rueckert, JC Escola-Gil, PT Kovanen - Biochimica et Biophysica …, 2016 - Elsevier
Whereas LDL-derived cholesterol accumulates in atherosclerotic lesions, HDL particles are
thought to facilitate removal of cholesterol from the lesions back to the liver thereby …

Metabolomics in diabetic complications

LA Filla, JL Edwards - Molecular BioSystems, 2016 - pubs.rsc.org
With a global prevalence of 9%, diabetes is the direct cause of millions of deaths each year
and is quickly becoming a health crisis. Major long-term complications of diabetes arise from …

Metabolomics and lipidomics profiling reveals hypocholesterolemic and hypolipidemic effects of arabinoxylan on type 2 diabetic rats

Q Nie, M Xing, H Chen, J Hu, S Nie - Journal of agricultural and …, 2019 - ACS Publications
Type 2 diabetes (T2D) is a pandemic disease chiefly characterized by hyperglycemia. In this
study, the combination of serum lipidomic and metabolomic approach was employed to …

Particle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failure

A Teis, G Cediel, N Amigó, J Julve, J Aranyó… - Scientific reports, 2021 - nature.com
Evidence regarding any association of HDL-particle (HDL-P) derangements and HDL-
cholesterol content with cardiovascular (CV) death in chronic heart failure (HF) is lacking. To …

Relapsing-remitting multiple sclerosis patients display an altered lipoprotein profile with dysfunctional HDL

W Jorissen, E Wouters, JF Bogie, T Vanmierlo… - Scientific reports, 2017 - nature.com
Lipoproteins modulate innate and adaptive immune responses. In the chronic inflammatory
disease multiple sclerosis (MS), reports on lipoprotein level alterations are inconsistent and …