Cell death is an essential process in all living organisms and occurs through different
mechanisms. The three main types of programmed cell death are apoptosis, pyroptosis, and …

Through their many and varied metabolic functions, mitochondria power life. Paradoxically,
mitochondria also have a central role in apoptotic cell death. Upon induction of …

NLRP3 inflammasome activation is a highly regulated process for controlling secretion of the
potent inflammatory cytokines IL-1β and IL-18 that are essential during bacterial infection …

Proteins of the B-cell lymphoma-2 (BCL-2) family control the intrinsic apoptosis pathway.
The pro-apoptotic BCL-2 proteins BAX and BAK can commit a cell to its programmed death …

The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures,
as they intimately communicate, forming very dynamic platforms termed mitochondria …

Mitochondrial outer membrane permeabilization (MOMP) is a key checkpoint in apoptosis
that activates the caspase cascade and irreversibly causes the majority of cells to die. The …

In multicellular organisms the regulated cell death apoptosis is critically important for both
ontogeny and homeostasis. Mitochondria are indispensable for stress-induced apoptosis …

The discovery of alternative signaling pathways that regulate cell death has revealed
multiple strategies for promoting cell death with diverse consequences at the tissue and …

Inhibitors of apoptosis (IAPs) are a family of proteins that play a significant role in the control
of programmed cell death (PCD). PCD is essential to maintain healthy cell turnover within …

Apoptosis is a form of programmed cell death critical for the development and homeostasis
of multicellular organisms. A key event within the mitochondrial pathway to apoptosis is the …