The integrin family of transmembrane adhesion receptors is essential for sensing and
adhering to the extracellular environment. Integrins are heterodimers composed of non …

Muscles are the major force producing tissue in the human body. While certain muscle types
specialize in producing maximum forces, others are very enduring. An extreme example is …

Integrin-mediated adhesion to the extracellular matrix involves a surprisingly large number
of intracellular proteins, the integrin-associated proteins (IAPs), which are a fraction of the …

Adipose tissue dysregulation in obesity strongly influences systemic metabolic homeostasis
and is often linked to insulin resistance (IR). However, the molecular mechanisms …

Extracellular matrix (ECM) elasticity is perceived by cells via focal adhesion structures,
which transduce mechanical cues into chemical signalling to conform cell behavior …

PINCH-1 is a cytoplasmic component of the cell-extracellular matrix (ECM) adhesion
machine that is frequently overexpressed in cancer. The functions and mechanism of PINCH …

Fluorescence recovery after photobleaching (FRAP) is a cutting-edge live-cell functional
imaging technique that enables the exploration of protein dynamics in individual cells and …

Coacervate microdroplets, formed via liquid–liquid phase separation, have been proposed
as a compartment model for the construction of artificial cells or organelles. However, these …

Drosophila embryonic somatic muscles represent a simple and tractable model system to
study the gene regulatory networks that control diversification of cell types. Somatic …

Abstract α-actinin superfamily houses the family of parvins, comprising α, β and γ isoforms in
the vertebrates and a single orthologue in the invertebrates. Parvin as an adaptor protein is …