Pyrazinamide resistance in Mycobacterium tuberculosis: Review and update
The global control and management of tuberculosis (TB) is faced with the formidable
challenge of worsening scenarios of drug-resistant disease. Pyrazinamide (PZA) is an …
challenge of worsening scenarios of drug-resistant disease. Pyrazinamide (PZA) is an …
The bewildering antitubercular action of pyrazinamide
Pyrazinamide (PZA) is a cornerstone antimicrobial drug used exclusively for the treatment of
tuberculosis (TB). Due to its ability to shorten drug therapy by 3 months and reduce disease …
tuberculosis (TB). Due to its ability to shorten drug therapy by 3 months and reduce disease …
Pyrazinamide resistance is caused by two distinct mechanisms: prevention of coenzyme A depletion and loss of virulence factor synthesis
Pyrazinamide (PZA) is a critical component of first-and second-line treatments of
tuberculosis (TB), yet its mechanism of action largely remains an enigma. We carried out a …
tuberculosis (TB), yet its mechanism of action largely remains an enigma. We carried out a …
Structural and free energy landscape of novel mutations in ribosomal protein S1 (rpsA) associated with pyrazinamide resistance
Resistance to key first-line drugs is a major hurdle to achieve the global end tuberculosis
(TB) targets. A prodrug, pyrazinamide (PZA) is the only drug, effective in latent TB …
(TB) targets. A prodrug, pyrazinamide (PZA) is the only drug, effective in latent TB …
Pyrazinoic acid inhibits mycobacterial coenzyme A biosynthesis by binding to aspartate decarboxylase PanD
P Gopal, W Nartey, P Ragunathan… - ACS infectious …, 2017 - ACS Publications
Previously, we showed that a major in vitro and in vivo mechanism of resistance to
pyrazinoic acid (POA), the bioactive component of the critical tuberculosis (TB) prodrug …
pyrazinoic acid (POA), the bioactive component of the critical tuberculosis (TB) prodrug …
Drug resistance gene mutations and treatment outcomes in MDR-TB: A prospective study in Eastern China
Q Liu, D Yang, B Qiu, L Martinez, Y Ji… - PLoS Neglected …, 2021 - journals.plos.org
Background Multidrug-resistant tuberculosis (MDR-TB) poses a serious challenge to TB
control. It is of great value to search for drug resistance mutation sites and explore the roles …
control. It is of great value to search for drug resistance mutation sites and explore the roles …
Dynamics insights into the gain of flexibility by Helix-12 in ESR1 as a mechanism of resistance to drugs in breast cancer cell lines
Incidents of breast cancer (BC) are on the rise on a daily basis and have proven to be the
most prevelant cause of death for women in both developed and developing countries …
most prevelant cause of death for women in both developed and developing countries …
Molecular mechanisms of action, resistance, detection to the first-line anti tuberculosis drugs: Rifampicin and pyrazinamide in the post whole genome sequencing era
Recent studies in addition to studies based on whole genome sequencing (WGS) of clinical
isolates of Mycobacterium tuberculosis (MTB) from diverse geographical regions have …
isolates of Mycobacterium tuberculosis (MTB) from diverse geographical regions have …
Characterization of pncA Mutations and Prediction of PZA Resistance in Mycobacterium tuberculosis Clinical Isolates From Chongqing, China
K Li, Z Yang, J Gu, M Luo, J Deng, Y Chen - Frontiers in Microbiology, 2021 - frontiersin.org
Pyrazinamide (PZA) is widely used to treat drug-sensitive or multidrug resistance
tuberculosis. However, conventional PZA susceptibility tests of clinical isolates are rather …
tuberculosis. However, conventional PZA susceptibility tests of clinical isolates are rather …
Molecular snapshot of Mycobacterium tuberculosis population in Kazakhstan: a country-wide study
Y Skiba, I Mokrousov, G Ismagulova, E Maltseva… - Tuberculosis, 2015 - Elsevier
Republic of Kazakhstan is among the 27 high multidrug-resistant tuberculosis (MDR-TB)
burden countries in the world. Here, we analyzed the population structure and …
burden countries in the world. Here, we analyzed the population structure and …