Effects of diabetes on microglial physiology: a systematic review of in vitro, preclinical and clinical studies

M Vargas-Soria, M García-Alloza… - Journal of …, 2023 - Springer
Diabetes mellitus is a heterogeneous chronic metabolic disorder characterized by the
presence of hyperglycemia, commonly preceded by a prediabetic state. The excess of blood …

Diabetic retinopathy: Involved cells, biomarkers, and treatments

J Ren, S Zhang, Y Pan, M Jin, J Li, Y Luo… - Frontiers in …, 2022 - frontiersin.org
Diabetic retinopathy (DR), a leading cause of vision loss and blindness worldwide, is
caused by retinal neurovascular unit dysfunction, and its cellular pathology involves at least …

[HTML][HTML] Elucidating glial responses to products of diabetes-associated systemic dyshomeostasis

DA Padovani-Claudio, CJ Ramos, ME Capozzi… - Progress in retinal and …, 2023 - Elsevier
Diabetic retinopathy (DR) is a leading cause of blindness in working age adults. DR has non-
proliferative stages, characterized in part by retinal neuroinflammation and ischemia, and …

Macrophage activation contributes to diabetic retinopathy

Y Zhang, A Zhou - Journal of Molecular Medicine, 2024 - Springer
Diabetic retinopathy (DR) is recognized as a neurovascular complication of diabetes, and
emerging evidence underscores the pivotal role of inflammation in its pathophysiology …

Single-cell RNA sequencing reveals roles of unique retinal microglia types in early diabetic retinopathy

Y Wang, X Yang, Y Zhang, L Hong, Z Xie… - Diabetology & Metabolic …, 2024 - Springer
Background The pathophysiological mechanisms of diabetic retinopathy (DR), a blinding
disease, are intricate. DR was thought to be a microvascular disease previously. However …

The role of adaptive immunity in diabetic retinopathy

M Xue, X Mao, M Chen, W Yin, S Yuan… - Journal of Clinical …, 2022 - mdpi.com
Diabetic retinopathy (DR) is currently one of the common causes of vision loss in working-
age adults. It is clinically diagnosed and classified according to the vascular changes in the …

Single‐cell RNA sequencing in exploring the pathogenesis of diabetic retinopathy

X Zhang, F Zhang, X Xu - Clinical and Translational Medicine, 2024 - Wiley Online Library
Diabetic retinopathy (DR) is a leading cause of irreversible blindness in the working‐age
populations. Despite decades of research on the pathogenesis of DR for clinical care, a …

Circulating immune cell phenotyping is potentially relevant for diabetic retinopathy risk assessment

B Li, X Zhao, Z Hong, Y Ding, Y Zhang - Diabetes Research and Clinical …, 2024 - Elsevier
Background Inflammation is believed to play a central role in the development of diabetes
mellitus and is a common feature of type 2 diabetes mellitus (T2DM). However, the …

The single-cell landscape of alternative transcription start sites of diabetic retina

P Mao, Y Shen, X Mao, K Liu, J Zhong - Experimental Eye Research, 2023 - Elsevier
More than half of mammalian protein-coding genes have multiple transcription start sites.
Alternative transcription start site (TSS) modulate mRNA stability, localization, and …

[PDF][PDF] 单细胞转录组测序在糖尿病视网膜病变中的应用

牛栋玲, 张妍春, 刘红莉 - 中华眼视光学与视觉科学杂志 - cjoovs.com
摘要糖尿病视网膜病变(DR) 是致工作人群眼盲的首位病因, 发病机制错综复杂, 尚未阐明.
单细胞转录组测序(scRNA-seq) 通过深入分析细胞异质性, 功能变化及相互作用 …