Small molecule modulators of antioxidant response pathway

W Hur, NS Gray - Current opinion in chemical biology, 2011 - Elsevier
Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that regulates Antioxidant
Response Element (ARE)-mediated transcription of a plethora of antioxidant and protective …

[HTML][HTML] An overview of Parkinson's disease: curcumin as a possible alternative treatment

A Patel, CA Olang, G Lewis, K Mandalaneni, N Anand… - Cureus, 2022 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of
dopaminergic neurons in the substantia nigra of the midbrain and basal ganglia, followed by …

Neuroprotective and neurorescue effects of a novel polymeric nanoparticle formulation of curcumin (NanoCurc™) in the neuronal cell culture and animal model …

B Ray, S Bisht, A Maitra, A Maitra… - Journal of Alzheimer's …, 2011 - content.iospress.com
Alzheimer's disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques within the
brain parenchyma followed by synaptic loss and neuronal death. Deposited Aβ reacts with …

Curcumin Promotes A-beta Fibrillation and Reduces Neurotoxicity in Transgenic Drosophila

I Caesar, M Jonson, KPR Nilsson, S Thor… - PloS one, 2012 - journals.plos.org
The pathology of Alzheimer's disease (AD) is characterized by the presence of extracellular
deposits of misfolded and aggregated amyloid-β (Aβ) peptide and intraneuronal …

ApoE3 mediated poly (butyl) cyanoacrylate nanoparticles containing curcumin: study of enhanced activity of curcumin against beta amyloid induced cytotoxicity using …

RS Mulik, J Mönkkönen, RO Juvonen… - Molecular …, 2010 - ACS Publications
Beta amyloid plays a main role in the pathophysiology of Alzheimer's disease by inducing
oxidative stress in the brain. Curcumin, a natural antioxidant, is known to inhibit beta amyloid …

Protective effects of lycopene against amyloid β-induced neurotoxicity in cultured rat cortical neurons

M Qu, L Li, C Chen, M Li, L Pei, F Chu, J Yang, Z Yu… - Neuroscience …, 2011 - Elsevier
The neurotoxicity of amyloid β (Aβ) has been implicated as a critical cause in the
pathogenesis of Alzheimer's disease (AD). Among antioxidant phytochemicals derived from …

Neuroprotective effect of curcumin on okadaic acid induced memory impairment in mice

N Rajasekar, S Dwivedi, S kumar Tota… - European journal of …, 2013 - Elsevier
Okadaic acid (OKA) has been observed to cause memory impairment in human subjects
having seafood contaminated with dinoflagellate (Helicondria okadai). OKA induces tau …

Curcumin protects mouse neuroblastoma Neuro-2A cells against hydrogen-peroxide-induced oxidative stress

XC Zhao, L Zhang, HX Yu, Z Sun, XF Lin, C Tan, RR Lu - Food Chemistry, 2011 - Elsevier
Curcumin has been traditionally used in China and India for food and medicinal purposes. It
has been shown to possess potent antioxidative activity both in vitro and in vivo. In the …

Potential protection of green tea polyphenols against intracellular amyloid beta-induced toxicity on primary cultured prefrontal cortical neurons of rats

XY Qin, Y Cheng, LC Yu - Neuroscience letters, 2012 - Elsevier
The present study was performed to explore the effect of green tea polyphenols on the
intracellular Aβ (iAβ)-induced toxicity to cultured rat primary prefrontal cortical neurons …

Curcumin protects pre-oligodendrocytes from activated microglia in vitro and in vivo

L He, H Chen, L Qian, G Chen, JS Buzby - Brain research, 2010 - Elsevier
Infection and inflammation leading to injury or death of pre-oligodendrocytes (preOLs) is one
of the principal initiating mechanisms in the pathogenesis of preterm periventricular …