[PDF][PDF] Novel approaches for vaccine development

MS Gebre, LA Brito, LH Tostanoski, DK Edwards… - Cell, 2021 - cell.com
Vaccines are critical tools for maintaining global health. Traditional vaccine technologies
have been used across a wide range of bacterial and viral pathogens, yet there are a …

[HTML][HTML] The emergence of Zika virus and its new clinical syndromes

TC Pierson, MS Diamond - Nature, 2018 - nature.com
Zika virus (ZIKV) is a mosquito-transmitted flavivirus that has emerged as a global health
threat because of its potential to generate explosive epidemics and ability to cause …

[HTML][HTML] Immunization against Zika by entrapping live virus in a subcutaneous self-adjuvanting hydrogel

H Hao, S Wu, J Lin, Z Zheng, Y Zhou, Y Zhang… - Nature Biomedical …, 2023 - nature.com
The threat of new viral outbreaks has heightened the need for ready-to-use vaccines that are
safe and effective. Here we show that a subcutaneous vaccine consisting of live Zika virus …

Zika, chikungunya, and other emerging vector-borne viral diseases

SC Weaver, C Charlier, N Vasilakis… - Annual review of …, 2018 - annualreviews.org
Arthropod-borne viruses (arboviruses) have a long history of emerging to infect humans, but
during recent decades, they have been spreading more widely and affecting larger …

[HTML][HTML] An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

H Xia, H Luo, C Shan, AE Muruato, BTD Nunes… - Nature …, 2018 - nature.com
Virus–host interactions determine an infection outcome. The Asian lineage of Zika virus
(ZIKV), responsible for the recent epidemics, has fixed a mutation in the NS1 gene after …

[HTML][HTML] Current status of Zika virus vaccines: successes and challenges

A Pattnaik, BR Sahoo, AK Pattnaik - Vaccines, 2020 - mdpi.com
The recently emerged Zika virus (ZIKV) spread to the Americas, causing a spectrum of
congenital diseases including microcephaly in newborn and Guillain-Barré syndrome (GBS) …

[PDF][PDF] Vaccine mediated protection against Zika virus-induced congenital disease

JM Richner, BW Jagger, C Shan, CR Fontes, KA Dowd… - Cell, 2017 - cell.com
The emergence of Zika virus (ZIKV) and its association with congenital malformations has
prompted the rapid development of vaccines. Although efficacy with multiple viral vaccine …

[HTML][HTML] Viral emerging diseases: challenges in developing vaccination strategies

M Trovato, R Sartorius, L D'Apice, R Manco… - Frontiers in …, 2020 - frontiersin.org
In the last decades, a number of infectious viruses have emerged from wildlife or re-
emerged, generating serious threats to the global health and to the economy worldwide …

Structural biology of Zika virus and other flaviviruses

SS Hasan, M Sevvana, RJ Kuhn… - Nature structural & …, 2018 - nature.com
Zika virus (ZIKV) is an enveloped, icosahedral flavivirus that has structural and functional
similarities to other human flavivirus pathogens such as dengue (DENV), West Nile (WNV) …

[HTML][HTML] Current advances in Zika vaccine development

Y Wang, L Ling, Z Zhang, A Marin-Lopez - Vaccines, 2022 - mdpi.com
Zika virus (ZIKV), an emerging arthropod-borne flavivirus, was first isolated in Uganda in
1947 from monkeys and first detected in humans in Nigeria in 1952; it has been associated …