Bridging condensins mediate compaction of mitotic chromosomes

G Forte, L Boteva, F Conforto, N Gilbert, PR Cook… - Journal of Cell …, 2024 - rupress.org
Eukaryotic chromosomes compact during mitosis into elongated cylinders—and not the
spherical globules expected of selfattracting long flexible polymers. This process is mainly …

Interphase chromosomes of the Aedes aegypti mosquito are liquid crystalline and can sense mechanical cues

VG Contessoto, O Dudchenko, E Aiden, PG Wolynes… - Biophysical …, 2023 - cell.com
Within the nucleus, the genome of eukaryotes folds into partially organized three-
dimensional structures specific to the cell type and phase of life. While the physical …

Motorized Chromosome Models of Mitosis

Z Cao, C Du, Z Hou, PG Wolynes - arXiv preprint arXiv:2501.09873, 2025 - arxiv.org
During mitosis, near-spherical chromosomes reconfigure into rod-like structures to ensure
their accurate segregation to daughter cells. We explore here, the interplay between the …

Bridging-mediated compaction of mitotic chromosomes

G Forte, L Boteva, N Gilbert, PR Cook, D Marenduzzo - bioRxiv, 2022 - biorxiv.org
Eukaryotic chromosomes compact during mitosis and meiosis into elongated cylinders–and
not the spherical globules expected of self-attracting long flexible polymers. This process is …

A Computational Model of Mechanical Stretching of Cultured Cells on a Flexible Membrane

MM Massidda, D Ashirov, A Demkov, A Sices, A Baker - bioRxiv, 2024 - biorxiv.org
Mechanical forces play a crucial role in regulating various biological processes within cells.
Recent student support that forces applied to cells can lead to nuclear deformation, and that …