Population pharmacokinetic (popPK) approaches have spread widely throughout clinical
pharmacology research, and every clinician should have some understanding of them. After …

Population pharmacokinetics consists of analyzing pharmacokinetic (PK) data collected in
groups of individuals. Population PK is widely used to guide drug development and to inform …

The pharmacokinetic variability of lamotrigine (LTG) plays a significant role in its dosing
requirements. Our goal here was to use noninvasive clinical parameters to predict the dose …

There has been rising interest in using model‐informed precision dosing to provide
personalized medicine to patients at the bedside. This methodology utilizes population …

Background Being one of the most widespread, pervasive, and troublesome illnesses in the
world, depression causes dysfunction in various spheres of individual and social life …

Current methods of dose determination have contributed to suboptimal and inequitable
health outcomes in underrepresented patient populations. The persistent demand to …

The first order conditional estimation (FOCE) method is still one of the parameter estimation
workhorses for nonlinear mixed effects (NLME) modeling used in population …

Abstract Background and Objectives First-order conditional estimation with interaction
(FOCEI) is one of the most commonly used estimation methods in nonlinear mixed effects …

For the purpose of population pharmacometric modeling, a variety of mathematic algorithms
are implemented in major modeling software packages to facilitate the maximum likelihood …

This is a population pharmacokinetic (PopPK) analysis to predict PK of edoxaban, a direct‐
acting oral anticoagulant, in nonvalvular atrial fibrillation (NVAF) patients with severe renal …