Structures and general transport mechanisms by the major facilitator superfamily (MFS)

D Drew, RA North, K Nagarathinam… - Chemical reviews, 2021 - ACS Publications
The major facilitator superfamily (MFS) is the largest known superfamily of secondary active
transporters. MFS transporters are responsible for transporting a broad spectrum of …

Chemical biology probes of mammalian GLUT structure and function

GD Holman - Biochemical Journal, 2018 - portlandpress.com
The structure and function of glucose transporters of the mammalian GLUT family of proteins
has been studied over many decades, and the proteins have fascinated numerous research …

WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) inhibits GLUT1-mediated sugar transport by binding reversibly at the exofacial sugar …

OA Ojelabi, KP Lloyd, AH Simon, JK De Zutter… - Journal of Biological …, 2016 - ASBMB
WZB117 (2-fluoro-6-(m-hydroxybenzoyloxy) phenyl m-hydroxybenzoate) inhibits passive
sugar transport in human erythrocytes and cancer cell lines and, by limiting glycolysis …

Upregulation of glucose uptake and hexokinase activity of primary human CD4+ T cells in response to infection with HIV-1

M Kavanagh Williamson, N Coombes, F Juszczak… - Viruses, 2018 - mdpi.com
Infection of primary CD4+ T cells with HIV-1 coincides with an increase in glycolysis. We
investigated the expression of glucose transporters (GLUT) and glycolytic enzymes in …

Structure of, and functional insight into the GLUT family of membrane transporters

W Long, CI Cheeseman - Cell Health and Cytoskeleton, 2015 - Taylor & Francis
This review examines the development of structure and function of the human GLUT
proteins, gene family hSLC2A. These proteins are essential for moving the key metabolites …

Ins and outs of rocker switch mechanism in major facilitator superfamily of transporters

S Sauve, J Williamson, A Polasa, M Moradi - Membranes, 2023 - mdpi.com
The major facilitator superfamily (MFS) of transporters consists of three classes of membrane
transporters: symporters, uniporters, and antiporters. Despite such diverse functions, MFS …

Red wine and green tea flavonoids are cis-allosteric activators and competitive inhibitors of glucose transporter 1 (GLUT1)-mediated sugar uptake

OA Ojelabi, KP Lloyd, JK De Zutter… - Journal of Biological …, 2018 - ASBMB
The antioxidant-and flavonoid-rich contents of red wine and green tea are reported to offer
protection against cancer, cardiovascular disease, and diabetes. Some studies, however …

Sequence determinants of GLUT1 oligomerization: analysis by homology-scanning mutagenesis

JK De Zutter, KB Levine, D Deng… - Journal of Biological …, 2013 - ASBMB
The human blood-brain barrier glucose transport protein (GLUT1) forms homodimers and
homotetramers in detergent micelles and in cell membranes, where the GLUT1 oligomeric …

Effect of high glucose condition on glucose metabolism in primary astrocytes

K Staricha, N Meyers, J Garvin, Q Liu, K Rarick… - Brain research, 2020 - Elsevier
In the brain, glucose enters astrocytes through glucose transporter (GLUT1) and either
enters glycolysis or the glycogen shunt. Astrocytes meet the energy needs of neurons by …

Mechanistic insights into protein stability and self-aggregation in GLUT1 genetic variants causing GLUT1-deficiency syndrome

M Raja, RKH Kinne - The Journal of membrane biology, 2020 - Springer
Human sodium-independent glucose cotransporter 1 (hGLUT1) has been studied for its
tetramerization and multimerization at the cell surface. Homozygous or compound …