Monogenic diabetes includes several clinical conditions generally characterized by early-
onset diabetes, such as neonatal diabetes, maturity-onset diabetes of the young (MODY) …

The mechanisms of two programmed cell death pathways, autophagy, and apoptosis, are
extensively focused areas of research in the context of cancer. Both the catabolic pathways …

Monogenic diabetes results from one or more defects in a single gene. The disease may be
inherited within families as a dominant, recessive or non-Mendelian trait or may present as a …

ISPAD Clinical Practice Consensus Guidelines 2022: The diagnosis and management of
monogenic diabetes in children and adolescents - PMC Back to Top Skip to main content NIH …

Background Pancreatic β cell dysfunction and death are central in the pathogenesis of most
if not all forms of diabetes. Understanding the molecular mechanisms underlying β cell …

Autophagy is an intracellular degradation process responsible for the delivery of cellular
material to the lysosomes. One of the key mechanisms for control of autophagy is the …

Monogenic diabetes results from one or more defects in a single gene. The disease may be
inherited within families as a dominant, recessive, or non-Mendelian trait or may present as …

Significance: Cancer cells accumulate high levels of iron and reactive oxygen species
(ROS) to promote their high metabolic activity and proliferation rate. However, high levels of …

Background Wolfram syndrome (WS), a rare genetic disorder, is considered the best
prototype of endoplasmic reticulum (ER) diseases. Classical WS features are childhood …

To date, more than 30 genes have been linked to monogenic diabetes. Candidate gene and
genome-wide association studies have identified> 50 susceptibility loci for common type 1 …