Collaborative efforts driving progress in pediatric acute myeloid leukemia

CM Zwaan, EA Kolb, D Reinhardt… - Journal of clinical …, 2015 - ascopubs.org
Diagnosis, treatment, response monitoring, and outcome of pediatric acute myeloid
leukemia (AML) have made enormous progress during the past decades. Because AML is a …

Gemtuzumab ozogamicin in acute myeloid leukemia

CD Godwin, RP Gale, RB Walter - Leukemia, 2017 - nature.com
CD33 is variably expressed on leukemia blasts in almost all patients with acute myeloid
leukemia (AML) and possibly leukemia stem cells in some. Efforts to target CD33 …

Gemtuzumab ozogamicin in children and adolescents with de novo acute myeloid leukemia improves event-free survival by reducing relapse risk: results from the …

AS Gamis, TA Alonzo, S Meshinchi, L Sung… - Journal of Clinical …, 2014 - ascopubs.org
Purpose To improve survival rates in children with acute myeloid leukemia (AML), we
evaluated gemtuzumab-ozogamicin (GO), a humanized immunoconjugate targeted against …

Pediatric AML: from biology to clinical management

JDE De Rooij, CM Zwaan… - Journal of clinical …, 2015 - mdpi.com
Pediatric acute myeloid leukemia (AML) represents 15%–20% of all pediatric acute
leukemias. Survival rates have increased over the past few decades to~ 70%, due to …

[HTML][HTML] Bortezomib with standard chemotherapy for children with acute myeloid leukemia does not improve treatment outcomes: a report from the Children's Oncology …

R Aplenc, S Meshinchi, L Sung, T Alonzo, J Choi… - …, 2020 - ncbi.nlm.nih.gov
New therapeutic strategies are needed for pediatric acute myeloid leukemia (AML) to reduce
disease recurrence and treatment-related morbidity. The Children's Oncology Group Phase …

Pediatric acute myeloid leukemia—past, present, and future

D Reinhardt, E Antoniou, K Waack - Journal of clinical medicine, 2022 - mdpi.com
JCM | Free Full-Text | Pediatric Acute Myeloid Leukemia—Past, Present, and Future Next
Article in Journal Sexual Habits and Sexual Dysfunctions in a Sample of Patients with Psychotic …

Pediatric acute myeloid leukemia: updates on biology, risk stratification, and therapy

CW Elgarten, R Aplenc - Current Opinion in Pediatrics, 2020 - journals.lww.com
Further incorporation of genomic and molecular data in pediatric AML will allow for
additional refinements in risk stratification to enable the tailoring of treatment intensity. These …

Gemtuzumab Ozogamicin Improves Event-Free Survival and Reduces Relapse in Pediatric KMT2A-Rearranged AML: Results From the Phase III Children's Oncology …

JA Pollard, E Guest, TA Alonzo, RB Gerbing… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE We investigated the impact of the CD33-targeted agent gemtuzumab ozogamicin
(GO) on survival in pediatric patients with KMT2A-rearranged (KMT2A-r) acute myeloid …

Immunotherapy in hematologic malignancies: achievements, challenges and future prospects

L Tang, Z Huang, H Mei, Y Hu - Signal Transduction and Targeted …, 2023 - nature.com
The immune-cell origin of hematologic malignancies provides a unique avenue for the
understanding of both the mechanisms of immune responsiveness and immune escape …

Results of the AIEOP AML 2002/01 multicenter prospective trial for the treatment of children with acute myeloid leukemia

A Pession, R Masetti, C Rizzari, MC Putti… - Blood, The Journal …, 2013 - ashpublications.org
We evaluated the outcome of 482 children with acute myeloid leukemia (AML) enrolled in
the Associazione Italiana di Ematologia e Oncologia Pediatrica AML 2002/01 trial …