The management of metastatic GIST: current standard and investigational therapeutics

CM Kelly, L Gutierrez Sainz, P Chi - Journal of Hematology & Oncology, 2021 - Springer
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the
gastrointestinal tract. The majority of GISTs harbor gain of function mutations in either KIT or …

Gastrointestinal stromal tumours: origin and molecular oncology

CL Corless, CM Barnett, MC Heinrich - Nature Reviews Cancer, 2011 - nature.com
Gastrointestinal stromal tumours (GISTs) are a paradigm for the development of
personalized treatment for cancer patients. The nearly simultaneous discovery of a …

NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors

GD Demetri, M Von Mehren, CR Antonescu… - Journal of the National …, 2010 - jnccn.org
Background Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal
tumors of the gastrointestinal tract. Neoplastic GIST cells seem to arise from a common …

Risk stratification of patients diagnosed with gastrointestinal stromal tumor

H Joensuu - Human pathology, 2008 - Elsevier
Accurate risk stratification of gastrointestinal stromal tumors (GISTs) has become
increasingly important owing to emerging adjuvant systemic treatments. All GISTs have …

Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis

M Miettinen, J Lasota - Archives of pathology & laboratory …, 2006 - meridian.allenpress.com
Abstract Context.—Gastrointestinal stromal tumors (GISTs) are specific, generally Kit
(CD117)-positive, mesenchymal tumors of the gastrointestinal tract encompassing a majority …

NCCN Task Force report: management of patients with gastrointestinal stromal tumor (GIST)—update of the NCCN clinical practice guidelines

GD Demetri, RS Benjamin, CD Blanke, JY Blay… - Journal of the National …, 2007 - jnccn.org
The NCCN Soft Tissue Sarcoma Guidelines include a subsection about treatment
recommendations for gastrointestinal stromal tumors (GISTs). The standard of practice …

Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal …

JS Gold, M Gönen, A Gutiérrez, JM Broto… - The lancet …, 2009 - thelancet.com
Background Adjuvant imatinib mesylate prolongs recurrence-free survival (RFS) after
resection of localised primary gastrointestinal stromal tumours (GIST). We aimed to develop …

Gastrointestinal stromal tumors

M Miettinen, J Lasota - Gastroenterology Clinics, 2013 - gastro.theclinics.com
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the
gastrointestinal (GI) tract. Soon after GIST was recognized as a tumor driven by a KIT or …

Effect of KIT and PDGFRA mutations on survival in patients with gastrointestinal stromal tumors treated with adjuvant imatinib: an exploratory analysis of a randomized …

H Joensuu, E Wardelmann, H Sihto, M Eriksson… - JAMA …, 2017 - jamanetwork.com
Importance Little is known about whether the duration of adjuvant imatinib influences the
prognostic significance of KIT proto-oncogene receptor tyrosine kinase (KIT) and platelet …

[HTML][HTML] The GIST of advances in treatment of advanced gastrointestinal stromal tumor

IM Schaefer, RP DeMatteo… - American Society of …, 2022 - ncbi.nlm.nih.gov
Gastrointestinal stromal tumor (GIST) is the most common malignant neoplasm of
mesenchymal origin and a compelling clinical and biologic model for the rational …