Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1

Q Zhang, K Shi, D Yoo - Virology, 2016 - Elsevier
Type I interferons (IFN-α/β) are the major components of the innate immune response of
hosts, and in turn many viruses have evolved to modulate the host response during …

Equine viral arteritis: a respiratory and reproductive disease of significant economic importance to the equine industry

UBR Balasuriya, M Carossino… - Equine Veterinary …, 2018 - Wiley Online Library
Equine arteritis virus is the causative agent of equine viral arteritis, a respiratory and
reproductive disease that affects the members of the family Equidae. The virus was first …

Modulation of innate immune signaling by nonstructural protein 1 (nsp1) in the family Arteriviridae

M Han, D Yoo - Virus research, 2014 - Elsevier
Arteriviruses infect immune cells and may cause persistence in infected hosts. Inefficient
induction of pro-inflammatory cytokines and type I IFNs are observed during infection of this …

Inhibition of NF-κB activity by the porcine epidemic diarrhea virus nonstructural protein 1 for innate immune evasion

Q Zhang, J Ma, D Yoo - Virology, 2017 - Elsevier
Porcine epidemic diarrhea virus emerged in the US is known to suppress the type I
interferons response during infection. In the present study using porcine epithelial cells, we …

Impact of the host immune response on the development of equine herpesvirus myeloencephalopathy in horses

KS Giessler, LS Goehring, SI Jacob… - Journal of General …, 2024 - microbiologyresearch.org
Herpesviruses establish a well-adapted balance with their host's immune system. Despite
this co-evolutionary balance, infections can lead to severe disease including neurological …

Predicting postoperative length of stay for isolated coronary artery bypass graft patients using machine learning

F Alshakhs, H Alharthi, N Aslam, IU Khan… - International Journal of …, 2020 - Taylor & Francis
Purpose Predictive analytics (PA) is a new trending approach in the field of healthcare that
uses machine learning to build a prediction model using supervised learning algorithms …

Programmed− 2/− 1 ribosomal frameshifting in simarteriviruses: an evolutionarily conserved mechanism

Y Li, AE Firth, I Brierley, Y Cai, S Napthine… - Journal of …, 2019 - Am Soc Microbiol
ABSTRACT The− 2/− 1 programmed ribosomal frameshifting (− 2/− 1 PRF) mechanism in
porcine reproductive and respiratory syndrome virus (PRRSV) leads to the translation of two …

Domain organization and evolution of the highly divergent 5′ coding region of genomes of arteriviruses, including the novel possum nidovirus

A Gulyaeva, M Dunowska, E Hoogendoorn… - Journal of …, 2017 - Am Soc Microbiol
In five experimentally characterized arterivirus species, the 5′-end genome coding region
encodes the most divergent nonstructural proteins (nsp's), nsp1 and nsp2, which include …

Evasion of interferon-mediated immune response by arteriviruses

Z Jian, R Ma, L Zhu, H Deng, F Li, J Zhao… - Frontiers in …, 2022 - frontiersin.org
IFN is the most potent antiviral cytokine required for the innate and adaptive immune
responses, and its expression can help the host defend against viral infection. Arteriviruses …

Interactions of Equine Viruses with the Host Kinase Machinery and Implications for One Health and Human Disease

C Anderson, H Baha, N Boghdeh, M Barrera, F Alem… - Viruses, 2023 - mdpi.com
Zoonotic pathogens that are vector-transmitted have and continue to contribute to several
emerging infections globally. In recent years, spillover events of such zoonotic pathogens …