The blood‐brain barrier (BBB), as a crucial gate of brain‐blood molecular exchange, is
involved in the pathogenesis of multiple neurological diseases. Oxidative stress is caused …

The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status
that is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP: ATP …

The ancestors of marine mammals once roamed the land and independently committed to
an aquatic lifestyle. These macroevolutionary transitions have intrigued scientists for …

All cells must maintain a high ratio of cellular ATP: ADP to survive. Because of the adenylate
kinase reaction (2ADP↔ ATP+ AMP), AMP rises whenever the ATP: ADP ratio falls, and a …

The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status. It is
activated, by a mechanism requiring the tumor suppressor LKB1, by metabolic stresses that …

The LKB1→ AMPK cascade is switched on by metabolic stresses that either inhibit ATP
production (eg hypoxia, hypoglycaemia) or that accelerate ATP consumption (eg muscle …

As the liver is central in the maintenance of glucose homeostasis and energy storage,
knowledge of the physiology as well as physiopathology of hepatic energy metabolism is a …

Adenylate kinase and downstream AMP signaling is an integrated metabolic monitoring
system which reads the cellular energy state in order to tune and report signals to metabolic …

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common,
potentially lethal, monogenic diseases and is caused predominantly by mutations in …

Renal cyst development and expansion in autosomal dominant polycystic kidney disease
(ADPKD) involves both fluid secretion and abnormal proliferation of cyst-lining epithelial …