Mendelian randomization for cardiovascular diseases: principles and applications

SC Larsson, AS Butterworth… - European heart journal, 2023 - academic.oup.com
Large-scale genome-wide association studies conducted over the last decade have
uncovered numerous genetic variants associated with cardiometabolic traits and risk factors …

Exercise sustains the hallmarks of health

Y Qiu, B Fernández-García, HI Lehmann, G Li… - Journal of sport and …, 2023 - Elsevier
Exercise has long been known for its active role in improving physical fitness and sustaining
health. Regular moderate-intensity exercise improves all aspects of human health and is …

Causal relationship between physical activity, leisure sedentary behaviors and COVID-19 risk: a Mendelian randomization study

X Chen, X Hong, W Gao, S Luo, J Cai, G Liu… - Journal of translational …, 2022 - Springer
Background The 2019 coronavirus disease pandemic (COVID-19) poses an enormous
threat to public health worldwide, and the ensuing management of social isolation has …

Causal relationship between gut microbiota and gastrointestinal diseases: a mendelian randomization study

K Wu, Q Luo, Y Liu, A Li, D Xia, X Sun - Journal of Translational Medicine, 2024 - Springer
Background Recent research increasingly highlights a strong correlation between gut
microbiota and the risk of gastrointestinal diseases. However, whether this relationship is …

Does exercise prevent major non‐communicable diseases and premature mortality? A critical review based on results from randomized controlled trials

M Ballin, P Nordström - Journal of Internal Medicine, 2021 - Wiley Online Library
Observational studies show that physical activity is strongly associated with a reduced risk of
premature mortality and major non‐communicable diseases. We reviewed to which extent …

Causal association between sedentary behaviors and health outcomes: a systematic review and meta-analysis of mendelian randomization studies

Y Gao, Q Li, L Yang, H Zhao, D Wang, AJ Pesola - Sports Medicine, 2024 - Springer
Background Different types of sedentary behavior are associated with several health
outcomes, but the causality of these associations remains unclear. Objectives To conduct a …

Causal relationship between 731 immune cells and the risk of diabetic nephropathy: a two‑sample bidirectional Mendelian randomization study

S Song, Y Sun, J Yu - Renal Failure, 2024 - Taylor & Francis
Objective Previous observational studies have indicated associations between various
immune cells and diabetic nephropathy (DN). However, the causality remains unclear. We …

Is sedentary behavior a novel risk factor for cardiovascular disease?

AT Duran, E Romero, KM Diaz - Current Cardiology Reports, 2022 - Springer
Abstract Purpose of Review Review the most recent evidence on the role of sedentary
behavior in the prevention of cardiovascular disease (CVD). Recent Findings Prospective …

Causal association of physical activity with low back pain, intervertebral disc degeneration and sciatica: A two-sample mendelian randomization analysis study

X Guan, D Zhang, F Zhang, Y Zong, H Wang… - Frontiers in Cell and …, 2023 - frontiersin.org
Objective: Previous studies are insufficient to confirm a causal association between physical
activity (PA) and low back pain (LBP), intervertebral disc degeneration (IDD), and sciatica …

Polygenic score for physical activity is associated with multiple common diseases

E Sillanpää, T Palviainen, S Ripatti… - … and science in …, 2021 - pmc.ncbi.nlm.nih.gov
Introduction Genetic pleiotropy, in which the same genes affect two or more traits, may
partially explain the frequently observed associations between high physical activity (PA) …