Signaling pathways in brain tumors and therapeutic interventions
S Li, C Wang, J Chen, Y Lan, W Zhang… - … and Targeted Therapy, 2023 - nature.com
Brain tumors, although rare, contribute to distinct mortality and morbidity at all ages.
Although there are few therapeutic options for brain tumors, enhanced biological …
Although there are few therapeutic options for brain tumors, enhanced biological …
Molecular alterations in meningioma: prognostic and therapeutic perspectives
The mutational landscape of meningioma has expanded following the use of the new
genetic sequencing approaches. Novel mutations have been characterized and reveal their …
genetic sequencing approaches. Novel mutations have been characterized and reveal their …
Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities
Meningiomas are the most common primary intracranial tumors. There are no effective
medical therapies for meningioma patients, and new treatments have been encumbered by …
medical therapies for meningioma patients, and new treatments have been encumbered by …
Associations of meningioma molecular subgroup and tumor recurrence
Background We and others have identified mutually exclusive molecular subgroups of
meningiomas; however, the implications of this classification for clinical prognostication …
meningiomas; however, the implications of this classification for clinical prognostication …
Distinct genomic subclasses of high-grade/progressive meningiomas: NF2-associated, NF2-exclusive, and NF2-agnostic
Background Genomic studies of high-grade/progressive meningiomas have reported a
heterogeneous mutation spectrum, identifying few recurrently mutated genes. Most studies …
heterogeneous mutation spectrum, identifying few recurrently mutated genes. Most studies …
Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas
Hedgehog signaling mediates embryologic development of the central nervous system and
other tissues and is frequently hijacked by neoplasia to facilitate uncontrolled cellular …
other tissues and is frequently hijacked by neoplasia to facilitate uncontrolled cellular …
The Simpson grade: abandon the scale but preserve the message
TH Schwartz, MW McDermott - Journal of Neurosurgery, 2020 - thejns.org
The Simpson grading scale, developed in 1957 by Donald Simpson, has been considered
the gold standard for defining the surgical extent of resection for WHO grade I meningiomas …
the gold standard for defining the surgical extent of resection for WHO grade I meningiomas …
Meningioma: International Consortium on Meningiomas consensus review on scientific advances and treatment paradigms for clinicians, researchers, and patients
Meningiomas are the most common primary intracranial tumors in adults and are increasing
in incidence due to the aging population and increased access to neuroimaging. While most …
in incidence due to the aging population and increased access to neuroimaging. While most …
Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features
Background Meningiomas, the most common primary intracranial tumors, can be separated
into 3 DNA methylation groups with distinct biological drivers, clinical outcomes, and …
into 3 DNA methylation groups with distinct biological drivers, clinical outcomes, and …
Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease
While somatic variants of TRAF7 (Tumor necrosis factor receptor-associated factor 7)
underlie anterior skull-base meningiomas, here we report the inherited mutations of TRAF7 …
underlie anterior skull-base meningiomas, here we report the inherited mutations of TRAF7 …