Diabetes is a major risk factor for cardiovascular diseases, including diabetic
cardiomyopathy, atherosclerosis, myocardial infarction, and heart failure. As cardiovascular …

Biological tissues are fed by arterial networks whose task is to set blood flow delivery in
accordance with energetic demand. Coordinating vasomotor activity among hundreds of …

Abstract Ischemia/reperfusion (I/R)-induced liver injury with severe cell death is a major
complication of liver transplantation. Transmembrane member 16A (TMEM16A), a …

Systemic blood pressure is acutely controlled by total peripheral resistance as determined
by the diameter of small arteries and arterioles, the contractility of which is regulated by …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses the Angiotensin
converting enzyme 2 (ACE2) receptor present on the cell surface to enter cells. Angiotensin …

Pressure-dependent chronotropy of murine lymphatic collecting vessels relies on the
activation of the Ca2+-activated chloride channel encoded by Anoctamin 1 (Ano1) in …

Pulmonary arterial (PA) smooth muscle cells (PASMC) generate vascular tone in response
to agonists coupled to Gq-protein receptor signaling. Such agonists stimulate oscillating …

The TMEM16A Ca 2+-gated Cl− channel is involved in a variety of vital physiological
functions and may be targeted pharmacologically for therapeutic benefit in diseases such as …

Ca2+ signalling plays a crucial role in determining lymphatic muscle cell excitability and
contractility through its interaction with the Ca2+‐activated Cl− channel anoctamin 1 (ANO1) …

Obesity and metabolic syndrome pose a significant risk for developing cardiovascular
disease and remain a critical healthcare challenge. Given the lymphatic system's role as a …