SUMOylation, as a post-translational modification, plays essential roles in various biological
functions including cell growth, migration, cellular responses to stress and tumorigenesis …

Lysine post-translational modifications (PTMs) play a crucial role in regulating diverse
functions and biological processes of proteins. However, because of the large volumes of …

Small ubiquitin-like modifiers (SUMOs) regulate a variety of cellular processes through two
distinct mechanisms, including covalent sumoylation and non-covalent SUMO interaction …

Motivation: Post-translational modification by the Small Ubiquitin-like Modifier (SUMO)
proteins, a process termed SUMOylation, is involved in many fundamental cellular …

Formylation is a type of post-translational modification that can occur on lysine sites, which
plays an irreplaceable role in organism. To better understand the mechanism, it is necessary …

Translesion polymerase eta (polη) was characterized for its ability to replicate ultraviolet-
induced DNA lesions that stall replicative polymerases, a process promoted by Rad18 …

Despite the fact that alveolar macrophages play an important role in smoking-related
disease, little is known about what regulates their pathophysiologic phenotype. Evaluating …

Most modern tools used to predict sites of small ubiquitin-like modifier (SUMO) binding
(referred to as SUMOylation) use algorithms, chemical features of the protein, and …

Sumoylation is a powerful regulatory system that controls many of the critical processes in
the cell, including DNA repair, transcriptional regulation, nuclear transport, and DNA …

Sumoylation is one of the most essential mechanisms of reversible protein post-translational
modifications and is a crucial biochemical process in the regulation of a variety of important …