Epigenetic and transcriptional control of erythropoiesis

M Wells, L Steiner - Frontiers in Genetics, 2022 - frontiersin.org
Erythropoiesis is a process of enormous magnitude, with the average person generating two
to three million red cells every second. Erythroid progenitors start as large cells with large …

[HTML][HTML] NSD family proteins: Rising stars as therapeutic targets

L He, Y Cao, L Sun - Cell Insight, 2024 - Elsevier
Epigenetic modifications, including DNA methylation and histone post-translational
modifications, intricately regulate gene expression patterns by influencing DNA accessibility …

Nuclear receptor binding SET domain protein 1 promotes epithelial-mesenchymal transition in paclitaxel-resistant breast cancer cells via regulating nuclear factor …

Y Chen, W Tang, X Zhu, L Zhang, Y Zhu, H Xiao… - …, 2021 - Taylor & Francis
Breast cancer (BC) is regarded as the major cause of cancer-associated deaths in women.
Paclitaxel exerts a critical impact on the chemotherapy of BC, but the resistance to paclitaxel …

NSD1 Mutations in Sotos Syndrome Induce Differential Expression of Long Noncoding RNAs, miR646 and Genes Controlling the G2/M Checkpoint

G Conteduca, D Cangelosi, S Coco, M Malacarne… - Life, 2022 - mdpi.com
An increasing amount of evidence indicates the critical role of the NSD1 gene in Sotos
syndrome (SoS), a rare genetic disease, and in tumors. Molecular mechanisms affected by …

'Enhancing'red cell fate through epigenetic mechanisms

MP Rossmann, LI Zon - Current opinion in hematology, 2021 - journals.lww.com
As one of the best characterized and accessible cell differentiation systems, erythropoiesis
has been at the forefront of studies aiming to conceptualize how chromatin dynamics …