The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
S Datta, M Cano, K Ebrahimi, L Wang… - Progress in retinal and …, 2017 - Elsevier
The retinal pigment epithelium (RPE) is a highly specialized, unique epithelial cell that
interacts with photoreceptors on its apical side and with Bruch's membrane and the …
interacts with photoreceptors on its apical side and with Bruch's membrane and the …
Retinal microglia: just bystander or target for therapy?
Resident microglial cells can be regarded as the immunological watchdogs of the brain and
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …
IL-1 family members mediate cell death, inflammation and angiogenesis in retinal degenerative diseases
Inflammation underpins and contributes to the pathogenesis of many retinal degenerative
diseases. The recruitment and activation of both resident microglia and recruited …
diseases. The recruitment and activation of both resident microglia and recruited …
[HTML][HTML] VEGFR1 signaling in retinal angiogenesis and microinflammation
Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A,-B,–C,-D, and
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …
Retinal microglia–A key player in healthy and diseased retina
G Rathnasamy, WS Foulds, EA Ling, C Kaur - Progress in neurobiology, 2019 - Elsevier
Microglia, the resident immune cells of the brain and retina, are constantly engaged in the
surveillance of their surrounding neural tissue. During embryonic development they infiltrate …
surveillance of their surrounding neural tissue. During embryonic development they infiltrate …
Contribution of microglia‐mediated neuroinflammation to retinal degenerative diseases
MH Madeira, R Boia, PF Santos… - Mediators of …, 2015 - Wiley Online Library
Retinal degenerative diseases are major causes of vision loss and blindness worldwide and
are characterized by chronic and progressive neuronal loss. One common feature of retinal …
are characterized by chronic and progressive neuronal loss. One common feature of retinal …
CCR 2+ monocytes infiltrate atrophic lesions in age‐related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in …
F Sennlaub, C Auvynet, B Calippe… - EMBO molecular …, 2013 - embopress.org
Atrophic age‐related macular degeneration (AMD) is associated with the subretinal
accumulation of mononuclear phagocytes (MPs). Their role in promoting or inhibiting retinal …
accumulation of mononuclear phagocytes (MPs). Their role in promoting or inhibiting retinal …
Microglia versus monocytes: distinct roles in degenerative diseases of the retina
Unlike in the healthy mammalian retina, macrophages in retinal degenerative states are not
solely comprised of microglia but may include monocyte-derived recruits. Recent studies …
solely comprised of microglia but may include monocyte-derived recruits. Recent studies …
Ischemic retinopathies: oxidative stress and inflammation
JC Rivera, R Dabouz, B Noueihed… - Oxidative medicine …, 2017 - Wiley Online Library
Ischemic retinopathies (IRs), such as retinopathy of prematurity (ROP), diabetic retinopathy
(DR), and (in many cases) age‐related macular degeneration (AMD), are ocular disorders …
(DR), and (in many cases) age‐related macular degeneration (AMD), are ocular disorders …
On phagocytes and macular degeneration
Age related macular degeneration (AMD) is a complex multifactorial disease caused by the
interplay of age and genetic and environmental risk factors. A common feature observed in …
interplay of age and genetic and environmental risk factors. A common feature observed in …