Adeno-associated virus (AA V) is a human virus that can be propagated either as an
integrated provirus or by lytic infection (ATCHISON et al. 1965; HOGGAN et al. 1966, 1972) …

The members of the family Parvoviridae are among the smallest of the DNA viruses, with a
linear single-stranded genome of about 5 kilobases. Currently the family is divided into three …

A key feature in adeno‐associated virus (AAV) replication is efficient integration of the viral
genome into host cell DNA to establish latency when helper virus is absent. The steps …

Genetic studies of adeno-associated virus (AAV) indicate that two AAV genes are required
for viral DNA replication: the palindromic terminal repeat, which is the origin for DNA …

AAV is unique among eukaryotic viruses in the ability of its DNA to integrate preferentially
into a specific region of the human genome. Understanding AAV integration may aid in …

Using immunofluorescence and in situ hybridization techniques, we studied the intracellular
localization of adeno-associated virus type 2 (AAV-2) Rep proteins, VP proteins, and DNA …

Inverted terminal repeats (ITRs) are the only wild-type components retained in the genome
of adeno-associated virus (AAV) vectors. To determine whether ITR modification is a viable …

We have used baculovirus-expressed Rep68 that has been purified to homogeneity to
reexamine the binding properties of the Rep protein. We find that Rep68 is capable of …

The proteins encoded by the adeno-associated virus type 2 (AAV-2) rep and cap genes
obtained during a productive infection of HeLa cells with AAV-2 and adenovirus type 2 were …

Two adeno-associated virus (AAV) elements are necessary for the integration of the AAV
genome: Rep78/68 proteins and inverted terminal repeats (ITRs). To study the contribution …