A novel family of 2Fe–2S proteins, the NEET family, was discovered during the last decade
in numerous organisms, including archea, bacteria, algae, plant and human; suggesting an …

Iron–sulfur clusters (Fe–S) are one of the most ancient, ubiquitous and versatile classes of
metal cofactors found in nature. Proteins that contain Fe–S clusters constitute one of the …

Mitochondria are emerging as important players in the transformation process of cells,
maintaining the biosynthetic and energetic capacities of cancer cells and serving as one of …

MitoNEET is an outer mitochondrial membrane protein essential for sensing and regulation
of iron and reactive oxygen species (ROS) homeostasis. It is a key player in multiple human …

Cystic Fibrosis (CF) is a frequent and lethal autosomal recessive disease, caused by
mutations in the gene encoding the Cystic Fibrosis Transmembrane Conductance Regulator …

The specific role of the chloride anion (Cl−) as a signalling effector or second messenger
has been increasingly recognized in recent years. It could represent a key factor in the …

Iron-sulfur cluster biogenesis is executed by distinct protein assembly systems. Mammals
have two systems, the mitochondrial Fe-S cluster assembly system (ISC) and the cytosolic …

MitoNEET (mitochondrial protein containing Asn–Glu–Glu–Thr (NEET) sequence) is a 2Fe–
2S cluster-containing integral membrane protein that resides in the mitochondrial outer …

Immune evasion is a critical step of cancer progression that remains a major obstacle for
current T cell–based immunotherapies. Hence, we investigated whether it is possible to …

MitoNEET (mNEET) is a dimeric mitochondrial outer membrane protein implicated in many
facets of human pathophysiology, notably diabetes and cancer, but its molecular function …