Once myocardium dies during a heart attack, it is replaced by scar tissue over the course of
several weeks. The size, location, composition, structure and mechanical properties of the …

Heart failure is a major public health problem, with a patient population of at least 10 million
in Europe and approximately 5 million in North America. 1–3 Because of its age-dependent …

Known as the bible of biomedical engineering, The Biomedical Engineering Handbook,
Fourth Edition, sets the standard against which all other references of this nature are …

Ventricular wall stress is believed to be responsible for many physical mechanisms taking
place in the human heart, including ventricular remodeling, which is frequently associated …

Background Left ventricular (LV) wall stress reduction is a cornerstone in treating heart
failure. Large animal models and computer simulations indicate that adding non-contractile …

Objectives: We sought to determine whether patients with functional mitral regurgitation
(FMR) would benefit from ventricular reshaping by the Coapsys device (Myocor, Inc., Maple …

Computational modeling provides a potentially powerful way to integrate structural
properties measured in vitro to physiological functions measured in vivo. Focusing on the …

Transcatheter mitral valve replacement (TMVR) has been used for “off-label” treatment when
annuloplasty band ring for mitral repair fails. However, the complex anatomy and function of …

Heart failure continues to present a significant medical and economic burden throughout the
developed world. Novel treatments involving the injection of polymeric materials into the …

Summary MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) is a
transcatheter ventricular remodeling procedure. A transvenous tension element is placed …