Non-human primates in HIV research: Achievements, limits and alternatives
An ideal model for HIV-1 research is still unavailable. However, infection of non-human
primates (NHP), such as macaques, with Simian Immunodeficiency Virus (SIV) recapitulates …
primates (NHP), such as macaques, with Simian Immunodeficiency Virus (SIV) recapitulates …
Viremic non-progression in HIV/SIV infection: A tied game between virus and host
Á Bayón-Gil, J Martinez-Picado, MC Puertas - Cell Reports Medicine, 2025 - cell.com
High-efficacy antiretroviral treatment (ART) has been a game-changer for HIV/AIDS
pandemic, but incomplete CD4+ T cell recovery and persistent chronic immune activation …
pandemic, but incomplete CD4+ T cell recovery and persistent chronic immune activation …
The well-tempered SIV infection: Pathogenesis of SIV infection in natural hosts in the wild, with emphasis on virus transmission and early events post-infection that …
K Raehtz, I Pandrea, C Apetrei - Infection, Genetics and Evolution, 2016 - Elsevier
African NHPs are infected by over 40 different simian immunodeficiency viruses. These
viruses have coevolved with their hosts for long periods of time and, unlike HIV in humans …
viruses have coevolved with their hosts for long periods of time and, unlike HIV in humans …
Immunopathogenesis of simian immunodeficiency virus infection in nonhuman primates
JE Schmitz, B Korioth-Schmitz - Current opinion in HIV and AIDS, 2013 - journals.lww.com
Immunopathogenesis of simian immunodeficiency virus infectio... : Current Opinion in HIV and
AIDS Immunopathogenesis of simian immunodeficiency virus infection in nonhuman primates …
AIDS Immunopathogenesis of simian immunodeficiency virus infection in nonhuman primates …
Host–pathogen interaction in HIV infection
A Chowdhury, G Silvestri - Current opinion in immunology, 2013 - Elsevier
Highlights•Pattern of virus-infected CD4+ T cells as a key factor in HIV/AIDS
pathogenesis.•Novel properties of antiviral CTL responses described in macaques.• …
pathogenesis.•Novel properties of antiviral CTL responses described in macaques.• …
Cytotoxic T cell functions accumulate when CD4 is downregulated by CD4+ T cells in African green monkeys
CL Vinton, AM Ortiz, N Calantone, JC Mudd… - The Journal of …, 2017 - journals.aai.org
African green monkeys (AGMs) are a natural host of SIV that do not develop simian AIDS.
Adult AGMs naturally have low numbers of CD4+ T cells and a large population of MHC …
Adult AGMs naturally have low numbers of CD4+ T cells and a large population of MHC …
Homeostatic cytokines induce CD4 downregulation in African green monkeys independently of antigen exposure to generate simian immunodeficiency virus-resistant …
MR Perkins, JA Briant, N Calantone, S Whitted… - Journal of …, 2014 - Am Soc Microbiol
African green monkeys (AGMs; genus Chlorocebus) are a natural host of simian
immunodeficiency virus (SIVAGM). As they do not develop simian AIDS, there is great …
immunodeficiency virus (SIVAGM). As they do not develop simian AIDS, there is great …
Interleukin-2 therapy induces CD4 downregulation, which decreases circulating CD4 T cell counts, in African green monkeys
JC Mudd, MR Perkins, SR DiNapoli, VM Hirsch… - Journal of …, 2016 - Am Soc Microbiol
African green monkeys (AGMs) are natural hosts of simian immunodeficiency virus
(SIVAGM). Because these animals do not develop simian AIDS despite maintaining high …
(SIVAGM). Because these animals do not develop simian AIDS despite maintaining high …
Distinct cellular targets of SIV infection in natural and non-natural hosts of SIV
TH Vanderford, M Paiardini - Natural Hosts of SIV, 2014 - Elsevier
Natural hosts of SIV avoid AIDS despite high viral loads and lifelong infection. Studies
comparing the immunological characteristics of natural and non-natural hosts have revealed …
comparing the immunological characteristics of natural and non-natural hosts have revealed …
Early Events of SIVsab Mucosal Transmission in African Green Monkeys
KD Raehtz - 2019 - search.proquest.com
Unlike HIV infection in humans, SIV infection is generally nonpathogenic in natural hosts,
such as African green monkeys (AGMs), despite high life-long viral replication. Previous …
such as African green monkeys (AGMs), despite high life-long viral replication. Previous …