Superoxide, O2•−, is formed in all living organisms that come in contact with air, and,
depending upon its biological context, it may act as a signaling agent, a toxic species, or a …

Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

Biological molecules are often highly dynamic, and this flexibility can be critical for function.
The large range of sampled timescales and the fact that many of the conformers that are …

Cu/Zn superoxide dismutase (SOD1) is a frontline antioxidant enzyme catalysing superoxide
breakdown and is important for most forms of eukaryotic life. The evolution of aerobic …

The misfolding and mutation of Cu/Zn superoxide dismutase (SOD1) is commonly
associated with amyotrophic lateral sclerosis (ALS). SOD1 can accumulate within stress …

Biomolecules can be sequestered into membrane-less compartments, referred to as
biomolecular condensates. Experimental and computational methods have helped define …

The amino acid substitution or post‐translational modification of a cytosolic protein can
cause unpredictable changes to its electrophoretic mobility during SDS‐PAGE. This type of …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving
cytotoxic conformations of Cu, Zn superoxide dismutase (SOD1). A major challenge in …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
progressive demise of motor neurons. One of the causes of familial ALS is the mutation of …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the death of motor neurons. About 10% of ALS cases are inherited (familial), and a large …