Mitochondria, the organelle critical for cell survival and metabolism, are exploited by cancer
cells and provide an important therapeutic target in cancers. Mitochondria dynamically …

Anthracyclines constitute a fundamental part of the chemotherapy regimens utilized to treat a
number of different malignancies both in pediatric and adult patients. These drugs are one of …

Background The treatment of acute lymphoblastic leukemia (ALL) and osteosarcoma (OSC)
is very effective: the vast majority of patients recover and survive for decades. However, they …

Hypersensitivity reactions are the most frequent dose-limiting adverse reactions to
Escherichia coli-derived asparaginase in pediatric acute lymphoblastic leukemia (ALL) …

Several polymorphic gene variants within one-carbon metabolism, an essential pathway for
nucleotide synthesis and methylation reactions, are related to cancer risk. An aberrant DNA …

Acute lymphoblastic leukemia (ALL) is a malignant tumor common in children. Studies of
genetic susceptibility to cancer using biallelic insertion/deletion (INDEL) type polymorphisms …

Purpose There have been conflicting reports concerning the relationship between breast-
feeding and the development of atopic dermatitis (AD) in early childhood. The objective of …

Specific deletion of the tumor suppressor TRAF3 from B lymphocytes in mice leads to the
prolonged survival of mature B cells and expanded B cell compartments in secondary …

Background Non-small cell lung cancer (NSCLC) accounts for about 85% of all types of lung
cancer. Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) is involved in DNA …

Purpose Several lines of evidence indicate that the Hippo/Yes-associated protein 1 (YAP1)
pathways might play a role in the pathogenesis of asthma. To investigate the possible role of …