Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) are two different
entities sharing common clinical and physio-pathological features, with insulin resistance …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Purpose This review aimed to take stock of the current status of research on damage-
associated molecular pattern (DAMP) protein. We discuss the Janus-faced role of DAMP …

The nuclear protein high mobility group box 1 (HMGB1) has been suggested to be involved
in the pathogenesis of several vascular diseases such as systemic vasculitis and …

The endothelium plays a pivotal role in the progression of solid tumors and is considered a
highly relevant target for therapy. However, it emerges that current clinical angiogenesis …

High‐mobility group box protein 1 (HMGB1), a nonhistone nuclear protein and a cytokine
mediator, is implicated in the pathogenesis of rheumatoid arthritis (RA). Extracellular …

Stroke induces a complex web of pathophysiology that may evolve over hours to days and
weeks after onset. It is now recognized that inflammation is an important phenomenon that …

Carotid artery stenosis (CAS), an atherosclerotic disease of the carotid artery, is one of the
leading causes of transient ischemic attacks (TIA) and cerebrovascular attacks (CVA). The …

INTRODUCTION: Several clinical trials are currently evaluating stem cell therapy for patients
with critical limb ischemia that have no other surgical or endovascular options for …

HMGB1 is an architectural chromatin-binding protein that can be released actively by
activated cells or passively by dying cells and can serve as a DAMP molecule to drive the …