Extensively characterized, modified, and employed for a variety of purposes, adenovirus
(Ad) vectors are generally regarded as having great potential by many applied virologists …

Adenoviral vectors are a safe and potently immunogenic vaccine delivery platform. Non-
replicating Ad vectors possess several attributes which make them attractive vaccines for …

Adenoviruses have been studied intensively for over 50 years as models of virus–cell
interactions and latterly as gene vectors. With the advent of more sophisticated structural …

Currently, various oncolytic adenoviruses (OA) are being explored in both preclinical and
clinical virotherapy. However, the pre-existing neutralizing antibodies (nAbs) and poor …

Hepatic glucose production (HGP) maintains blood glucose levels during fasting but can
also exacerbate diabetic hyperglycemia. HGP is dynamically controlled by a signaling …

In the past 5 years, the field of oncolytic virus research has matured significantly and is
moving past the stage of being a laboratory novelty into a new era of preclinical and clinical …

Adenoviruses (Ad) are efficient vehicles for gene delivery in vitro and in vivo. Therefore, they
are a promising tool in gene therapy, particularly in the treatment of cancer and …

Oncolytic viruses (OVs) are selected or designed to eliminate malignancies by direct
infection and lysis of cancer cells. In contrast to this concept of direct tumor lysis by viral …

Adenovirus (Ad) vectors were initially developed for treatment of genetic diseases. Their
usefulness for permanent gene replacement was limited by their high immunogenicity …

Human species C adenovirus serotype 5 (Ad5) is the most common viral vector used in
clinical studies worldwide. Ad5 vectors infect liver cells in vivo with high efficiency via a …