Macrocycles are abundantly used by nature to enable cell‐permeable bioactive molecules.
Synthetic non‐peptidic macrocycles are also increasingly considered as modalities for …

Macrocycles are increasingly considered as promising modalities to target challenging
intracellular proteins. However, strategies for transitioning from active linear starting points to …

Most proteins are flexible molecules that coexist in an ensemble of several conformations.
Point mutations in the amino acid sequence of a protein can trigger structural changes that …