Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) identified in 2003
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …
[HTML][HTML] Strategies for the development and approval of COVID-19 vaccines and therapeutics in the post-pandemic period
D Ao, X He, J Liu, L Xu - Signal Transduction and Targeted Therapy, 2023 - nature.com
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted
in significant casualties and put immense strain on public health systems worldwide, leading …
in significant casualties and put immense strain on public health systems worldwide, leading …
The IUPHAR/BPS guide to pharmaCOLOGY in 2024
SD Harding, JF Armstrong, E Faccenda… - Nucleic acids …, 2024 - academic.oup.com
Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; https://www.
guidetopharmacology. org) is an open-access, expert-curated, online database that …
guidetopharmacology. org) is an open-access, expert-curated, online database that …
[HTML][HTML] Combination regimen of nirmatrelvir/ritonavir and molnupiravir for the treatment of persistent SARS-CoV-2 infection: A case report and a scoping review of the …
D Marangoni, RM Antonello, M Coppi… - International Journal of …, 2023 - Elsevier
Immunocompromised patients still experience unpredictable courses of COVID-19, despite
that effective vaccines and drugs against SARS-CoV-2 are now available. Antiviral …
that effective vaccines and drugs against SARS-CoV-2 are now available. Antiviral …
[HTML][HTML] Benzimidazole-triazole hybrids as antimicrobial and antiviral agents: A systematic review
M Marinescu - Antibiotics, 2023 - mdpi.com
Bacterial infections have attracted the attention of researchers in recent decades, especially
due to the special problems they have faced, such as their increasing diversity and …
due to the special problems they have faced, such as their increasing diversity and …
[HTML][HTML] Bone marrow mesenchymal stem cell-derived extracellular vesicle infusion for the treatment of respiratory failure from COVID-19: a randomized, placebo …
AL Lightner, V Sengupta, S Qian, JT Ransom, S Suzuki… - Chest, 2023 - Elsevier
Background Bone marrow mesenchymal stem cell (BM-MSC)-derived extracellular vesicles
(ExoFlo) convey the immunomodulatory and regenerative properties of intact BM-MSCs …
(ExoFlo) convey the immunomodulatory and regenerative properties of intact BM-MSCs …
Evaluation of in vitro antiviral activity of SARS-CoV-2 Mpro inhibitor pomotrelvir and cross-resistance to nirmatrelvir resistance substitutions
X Tong, W Keung, LD Arnold, LJ Stevens… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
The unprecedented scale of the COVID-19 pandemic and the rapid evolution of SARS-CoV-
2 variants underscore the need for broadly active inhibitors with a high barrier to resistance …
2 variants underscore the need for broadly active inhibitors with a high barrier to resistance …
[HTML][HTML] No time for complacency on COVID-19 in Europe
A Flahault, A Calmy, D Costagliola, O Drapkina… - The Lancet, 2023 - thelancet.com
COVID-19 continue to occur across Europe because of persistent viral circulation and the
regular emergence of new subvariants of omicron. 2 New infections occur even during the …
regular emergence of new subvariants of omicron. 2 New infections occur even during the …
[HTML][HTML] Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1
X Xie, Q Lan, J Zhao, S Zhang, L Liu, Y Zhang… - … and Targeted Therapy, 2024 - nature.com
Respiratory disease caused by coronavirus infection remains a global health crisis.
Although several SARS-CoV-2-specific vaccines and direct-acting antivirals are available …
Although several SARS-CoV-2-specific vaccines and direct-acting antivirals are available …
Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model
The emergence of SARS-CoV-2 variants and drug-resistant mutants calls for additional oral
antivirals. The SARS-CoV-2 papain-like protease (PLpro) is a promising but challenging …
antivirals. The SARS-CoV-2 papain-like protease (PLpro) is a promising but challenging …