Abstract Alzheimer's disease (AD), as the fourth leading cause of death among the elderly
worldwide, has brought enormous challenge to the society. Due to its extremely complex …

Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …

Neurodegenerative diseases represent nowadays one of the major health problems.
Despite the efforts made to unveil the mechanism leading to neurodegeneration, it is still not …

Nature products have been extensively used in the discovery and development of new
drugs, as the most important source of drugs. The triazole ring is one of main …

Fatty acid amide hydrolase (FAAH) is an important enzyme creditworthy of hydrolyzing
endocannabinoids and related-amidated signalling lipids, discovery of which has pioneered …

The endocannabinoid system is up-regulated in numerous pathophysiological states such
as inflammatory, neurodegenerative, gastrointestinal, metabolic and cardiovascular …

The endocannabinoid system (ECS) exerts a modulatory effect of important functions such
as neurotransmission, glial activation, oxidative stress, or protein homeostasis …

Hybridization is emerged as a promising strategy in the discovery of new drugs, especially
these with complimentary activities and multiple pharmacological targets that are the …

Neuroinflammation and cholinergic deficit are key detrimental processes involved in
Alzheimer's disease. Hence, in the search for novel and effective treatment strategies, the …

Polypharmacology breaks up the classical paradigm of “one-drug, one target, one disease”
electing multitarget compounds as potential therapeutic tools suitable for the treatment of …