Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

Highly ordered organisation of striated muscle is the prerequisite for the fast and
unidirectional development of force and motion during heart and skeletal muscle …

Sarcomeres are force-generating and load-bearing devices of muscles. A precise molecular
picture of how sarcomeres are built underpins understanding their role in health and …

The recent discovery of heterozygous human mutations that truncate full-length titin (TTN, an
abundant structural, sensory, and signaling filament in muscle) as a common cause of end …

Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) are common heart
muscle disorders that are caused by pathogenic variants in sarcomere protein genes. HCM …

Titin is a giant vertebrate striated muscle protein with critical importance for myofibril
elasticity and structural integrity. We show here that the complete sequence of the human …

The sarcomere contains, in addition to thin and thick filaments, a filament composed of the
giant protein titin (also known as connectin). Titin molecules anchor in the Z-disc and extend …

Muscle cells respond to mechanical stretch stimuli by triggering downstream signals for
myocyte growth and survival. The molecular components of the muscle stretch sensor are …

The 364 exon TTN gene encodes titin (TTN), the largest known protein, which plays key
structural, developmental, mechanical, and regulatory roles in cardiac and skeletal muscles …

▪ Abstract Striated muscle is an intricate, efficient, and precise machine that contains
complex interconnected cytoskeletal networks critical for its contractile activity. The …