Ym1 is a rodent-specific chitinase-like protein (CLP) lacking catalytic activity, whose cellular
origins are mainly macrophages, neutrophils and other cells. Although the detailed function …

Allergic asthma is a disease initiated by a breach of the lung mucosal barrier and an
inappropriate Th2 inflammatory immune response that results in M2 polarization of alveolar …

The concept that macrophages play an active role in inflammatory responses began its
development in the late 1800s with the now iconic studies by Elie Metchnikoff using starfish …

Monocytic cells exhibit a high level of heterogeneity and have two distinct modes of their
activation: 1) classical M1 path associated with inflammation and tissue damage, and 2) …

Infection with severe acute respiratory syndrome coronavirus (SARS-CoV) causes acute
lung injury (ALI) that often leads to severe lung disease. A mouse model of acute SARS-CoV …

Ym1 and RELMα are established effector molecules closely synonymous with Th2-type
inflammation and associated pathology. Here, we show that whilst largely dependent on IL …

Background The IL-4 receptor α (IL-4Rα) chain has a broad expression pattern and
participates in IL-4 and IL-13 signaling, allowing it to influence several pathological …

Endotoxin tolerance is a complex phenomenon characterized primarily by decreased
production of proinflammatory cytokines, chemokines, and other inflammatory mediators …

In this historical perspective, written in honor of Dr. William E. Paul, we describe the initial
discovery of one of the dominant substrates for tyrosine phosphorylation stimulated by IL-4 …

Background The mechanisms by which viruses cause asthma exacerbations are not
precisely known. Previously, we showed that, in ovalbumin (OVA)-sensitized and …