In recent years, due to the dramatic increase in and global spread of bacterial resistance to a
number of commonly used antibacterial agents, many studies have been directed at …

Background Ticagrelor is an oral antiplatelet drug that can reversibly bind to the platelet
P2Y12 receptor. Ticagrelor is metabolized mainly by CYP3A4 and produces a rapid blood …

The blood platelet plays an important role but often remains under‐recognized in several
vascular complications and associated diseases. Surprisingly, platelet hyperactivity and …

Mitochondria are central organelles in the homeostasis of the cardiovascular system via the
integration of several physiological processes, such as ATP generation via oxidative …

Adenosine is an endogenous nucleoside that regulates many physiological and
pathological processes. It is derived from either the intracellular or extracellular …

Severe fibrotic and thrombotic events permeate the healthcare system, causing suffering for
millions of patients with inflammatory disorders. As late-state consequences of chronic …

Abstract Background Platelet P2Y12 antagonist ticagrelor reduces mortality after acute
myocardial infarction (AMI) compared to clopidogrel, but the underlying mechanism is …

Platelets are megakaryocyte-derived fragments lacking nuclei and prepped to maintain
primary hemostasis by initiating blood clots on injured vascular endothelia. Pathologically …

Platelet extracellular vesicles (PEVs) are potential new biomarkers of platelet activation
which may allow us to predict and/or diagnose developing coronary thrombosis before …

Dipyridamole is an old anti-platelet and coronary vasodilator agent that inhibits platelet
phosphodiesterase and increases interstitial adenosine levels. Its use in coronary artery …