Zinc and its role in immunity and inflammation
P Bonaventura, G Benedetti, F Albarède… - Autoimmunity reviews, 2015 - Elsevier
Zinc (Zn) nutritional importance has been known for a long time, but in the last decades its
importance in immune modulation has arisen. This review aims at describing the …
importance in immune modulation has arisen. This review aims at describing the …
ZBTB transcription factors: key regulators of the development, differentiation and effector function of T cells
ZY Cheng, TT He, XM Gao, Y Zhao, J Wang - Frontiers in Immunology, 2021 - frontiersin.org
The development and differentiation of T cells represents a long and highly coordinated, yet
flexible at some points, pathway, along which the sequential and dynamic expressions of …
flexible at some points, pathway, along which the sequential and dynamic expressions of …
[HTML][HTML] Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells
Children with autism spectrum disorders often display dysregulated immune responses and
related gastrointestinal symptoms. However, the underlying mechanisms leading to the …
related gastrointestinal symptoms. However, the underlying mechanisms leading to the …
[HTML][HTML] Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine
OJ Harrison, N Srinivasan, J Pott, C Schiering… - Mucosal …, 2015 - Elsevier
Elevated levels of interleukin-18 (IL-18) are found in many chronic inflammatory disorders,
including inflammatory bowel disease (IBD), and polymorphisms in the IL18R1–IL18RAP …
including inflammatory bowel disease (IBD), and polymorphisms in the IL18R1–IL18RAP …
An integrated epigenomic and transcriptomic map of mouse and human αβ T cell development
Summary αβ lineage T cells, most of which are CD4+ or CD8+ and recognize MHC I-or MHC
II-presented antigens, are essential for immune responses and develop from CD4+ CD8+ …
II-presented antigens, are essential for immune responses and develop from CD4+ CD8+ …
[HTML][HTML] CD4+ Cytotoxic T cells–phenotype, function and transcriptional networks controlling their differentiation pathways
T Preglej, W Ellmeier - Immunology Letters, 2022 - Elsevier
The two major subsets of peripheral T cells are classically divided into the CD4+ T helper
cells and the cytotoxic CD8+ T cell lineage. However, the appearance of some effector …
cells and the cytotoxic CD8+ T cell lineage. However, the appearance of some effector …
CD4 CTL: living up to the challenge
H Cheroutre, MM Husain - Seminars in immunology, 2013 - Elsevier
During thymic development, thymocytes expressing a T cell receptor consisting of an alpha
and beta chain (TCRαβ), commit to either the cytotoxic-or T helper-lineage fate. This lineage …
and beta chain (TCRαβ), commit to either the cytotoxic-or T helper-lineage fate. This lineage …
Regulation of hematopoietic development by ZBTB transcription factors
T Maeda - International journal of hematology, 2016 - Springer
Hematopoietic development is governed by the coordinated expression of lineage-and
differentiation stage-specific genes. Transcription factors play major roles in this process and …
differentiation stage-specific genes. Transcription factors play major roles in this process and …
NuRD complex recruitment to Thpok mediates CD4+ T cell lineage differentiation
Although BTB–zinc finger (BTB-ZF) transcription factors control the differentiation of multiple
hematopoietic and immune lineages, how they function is poorly understood. The BTB-ZF …
hematopoietic and immune lineages, how they function is poorly understood. The BTB-ZF …
Transcriptional and epigenetic networks of helper T and innate lymphoid cells
The discovery of the specification of CD 4+ helper T cells to discrete effector 'lineages'
represented a watershed event in conceptualizing mechanisms of host defense and …
represented a watershed event in conceptualizing mechanisms of host defense and …