Studies in Drosophila have provided a detailed understanding of how programmed cell
death is regulated by steroid hormones during development. This work has defined a two …

Proper formation of adult insects requires the integration of spatial and temporal regulatory
axes. Whereas spatial information confers identity to each tissue, organ and appendage …

Nuclear receptors are a family of transcription factors with structurally conserved ligand
binding domains that regulate their activity. Despite intensive efforts to identify ligands, most …

The transcription factor Broad-Complex (BR-C) is required for differentiation of adult
structures as well as for the programmed death of obsolete larval organs during …

The insect fat body is an organ analogue to vertebrate adipose tissue and liver and functions
as a major organ for nutrient storage and energy metabolism. Similar to other larval organs …

Juvenile hormone (JH) regulates many developmental and physiological events in insects,
but its molecular mechanism remains conjectural. Here we report that genetic ablation of the …

Publisher Summary This chapter reviews the knowledge of the neuroendocrine basis for
ecdysis, focusing first on cellular and chemical signaling mechanisms that control gene …

We report a technique for fluorescence tomography that operates beyond the penetration
limits of tissue-sectioning fluorescence microscopy. The method uses multi-projection …

SWI/SNF ATP-dependent chromatin remodeling complexes (remodelers) perform critical
functions in eukaryotic gene expression control. BAP and PBAP are the fly representatives of …

Despite the identification of numerous key players of the cell death machinery, little is known
about their physiological role. Using RNA interference (RNAi) in vivo, we have studied the …