The placental epigenome as a molecular link between prenatal exposures and fetal health outcomes through the DOHaD hypothesis
S Lapehn, AG Paquette - Current environmental health reports, 2022 - Springer
Abstract Purpose of Review The developmental origins of health and disease (DOHaD)
hypothesis posits that the perinatal environment can impact fetal and later life health. The …
hypothesis posits that the perinatal environment can impact fetal and later life health. The …
Epigenetics of pregnancy: looking beyond the DNA code
D Zuccarello, U Sorrentino, V Brasson, L Marin… - Journal of assisted …, 2022 - Springer
Epigenetics is the branch of genetics that studies the different mechanisms that influence
gene expression without direct modification of the DNA sequence. An ever-increasing …
gene expression without direct modification of the DNA sequence. An ever-increasing …
[HTML][HTML] Placental epigenetic clocks: estimating gestational age using placental DNA methylation levels
The human pan-tissue epigenetic clock is widely used for estimating age across the entire
lifespan, but it does not lend itself well to estimating gestational age (GA) based on placental …
lifespan, but it does not lend itself well to estimating gestational age (GA) based on placental …
Placental programming, perinatal inflammation, and neurodevelopment impairment among those born extremely preterm
Individuals born extremely preterm are at significant risk for impaired neurodevelopment.
After discharge from the neonatal intensive care, associations between the child's well-being …
After discharge from the neonatal intensive care, associations between the child's well-being …
Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome
The placenta is the interface between maternal and fetal circulations, integrating maternal
and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as …
and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as …
A cross-cohort analysis of autosomal DNA methylation sex differences in the term placenta
Background Human placental DNA methylation (DNAme) data is a valuable resource for
studying sex differences during gestation, as DNAme profiles after delivery reflect the …
studying sex differences during gestation, as DNAme profiles after delivery reflect the …
Who's afraid of the X? Incorporating the X and Y chromosomes into the analysis of DNA methylation array data
Background Many human disease phenotypes manifest differently by sex, making the
development of methods for incorporating X and Y-chromosome data into analyses vital …
development of methods for incorporating X and Y-chromosome data into analyses vital …
Accurate ethnicity prediction from placental DNA methylation data
Background The influence of genetics on variation in DNA methylation (DNAme) is well
documented. Yet confounding from population stratification is often unaccounted for in …
documented. Yet confounding from population stratification is often unaccounted for in …
The application of epiphenotyping approaches to DNA methylation array studies of the human placenta
Background Genome-wide DNA methylation (DNAme) profiling of the placenta with Illumina
Infinium Methylation bead arrays is often used to explore the connections between in utero …
Infinium Methylation bead arrays is often used to explore the connections between in utero …
[HTML][HTML] Immuno-epigenetic signature derived in saliva associates with the encephalopathy of prematurity and perinatal inflammatory disorders
ELS Conole, K Vaher, MB Cabez, G Sullivan… - Brain, Behavior, and …, 2023 - Elsevier
Background Preterm birth is closely associated with a phenotype that includes brain
dysmaturation and neurocognitive impairment, commonly termed Encephalopathy of …
dysmaturation and neurocognitive impairment, commonly termed Encephalopathy of …