Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer

F Ye, S Dewanjee, Y Li, NK Jha, ZS Chen, A Kumar… - Molecular cancer, 2023 - Springer
Breast cancer is the second leading cause of death for women worldwide. The
heterogeneity of this disease presents a big challenge in its therapeutic management …

HER2 low, ultra-low, and novel complementary biomarkers: expanding the spectrum of HER2 positivity in breast cancer

K Venetis, E Crimini, E Sajjadi, C Corti… - Frontiers in molecular …, 2022 - frontiersin.org
HER2 status in breast cancer is assessed to select patients eligible for targeted therapy with
anti-HER2 therapies. According to the American Society of Clinical Oncology (ASCO) and …

The peptide vaccine of the future

A Nelde, HG Rammensee, JS Walz - Molecular & cellular proteomics, 2021 - ASBMB
The approach of peptide-based anticancer vaccination has proven the ability to induce
cancer-specific immune responses in multiple studies for various cancer entities. However …

Breast cancer vaccines: disappointing or promising?

SY Zhu, KD Yu - Frontiers in Immunology, 2022 - frontiersin.org
Breast cancer has become the most commonly diagnosed cancer globally. The relapse and
metastasis of breast cancer remain a great challenge despite advances in chemotherapy …

[HTML][HTML] Therapeutic vaccines for breast cancer: Has the time finally come?

C Corti, PPMB Giachetti, AMM Eggermont… - European Journal of …, 2022 - Elsevier
The ability to exploit the immune system as a weapon against cancer has revolutionised the
treatment of cancer patients, especially through immune checkpoint inhibitors (ICIs) …

Cancer vaccines for triple-negative breast cancer: a systematic review

M Hosseini, S Seyedpour, B Khodaei, AH Loghman… - Vaccines, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) is the subtype of breast cancer with the poorest
outcomes, and is associated with a high risk of relapse and metastasis. The treatment …

Immunotherapy for HER2-positive breast cancer: clinical evidence and future perspectives

E Agostinetto, F Montemurro, F Puglisi, C Criscitiello… - Cancers, 2022 - mdpi.com
Simple Summary Human epidermal growth factor receptor 2 (HER2) positive breast cancer
is a heterogeneous disease. Among different therapeutic approaches, immunotherapies …

Peptide-based vaccines in clinical phases and new potential therapeutic targets as a new approach for breast cancer: a review

ML Nicolas-Morales, A Luisa-Sanjuan… - Vaccines, 2022 - mdpi.com
Breast cancer is the leading cause of death in women from 20 to 59 years old. The
conventional treatment includes surgery, chemotherapy, hormonal therapy, and …

[HTML][HTML] Advancements in the treatment of triple-negative breast cancer: A narrative review of the literature

I Landry, V Sumbly, M Vest - Cureus, 2022 - ncbi.nlm.nih.gov
Triple-negative breast cancers (TNBCs) are aggressive tumors that are more common in
young women, African American populations, and those with hereditary mutations. These …

Application of HER2 peptide vaccines in patients with breast cancer: a systematic review and meta-analysis

Z You, W Zhou, J Weng, H Feng, P Liang, Y Li… - Cancer Cell …, 2021 - Springer
Abstract Background The E75 and GP2 vaccines are the few therapeutic vaccines targeting
HER2 currently under clinical research for patients with breast cancer. Methods Databases …