Appropriate and timely cervical remodeling is key for successful birth. Premature cervical
opening can result in preterm birth which occurs in 12.5% of pregnancies. Research focused …

This review assessed the efficacy and safety of pharmacologic agents (prostaglandins,
oxytocin, mifepristone, hyaluronidase, and nitric oxide donors) and mechanical methods …

BACKGROUND: More than 150,000 pregnant women in England and Wales have their
labour induced each year. Multiple pharmacological, mechanical and complementary …

Proper cervical function is essential for a normal pregnancy and birth to occur.
Understanding the mechanisms that take place in normal pregnancy will allow a better …

Background Women with a prior caesarean delivery have an increased risk of uterine
rupture and for women subsequently requiring induction of labour it is unclear which method …

In normal pregnancy, the cervix maintains its shape during a period of substantial fetal and
uterine growth. Hence, maintenance of biomechanical integrity is an important aspect of …

Glycosaminoglycans (GAG) have diverse functions that regulate macromolecular assembly
in the extracellular matrix. During pregnancy, the rigid cervix transforms to a pliable structure …

At the end of gestation, the cervical tissue changes profoundly. As a result of these changes,
the uterine cervix becomes soft and vulnerable to dilation. The process occurring in the …

Background Induction of labour is carried out for a variety of indications and using a range of
methods. For women at low risk of pregnancy complications, some methods of induction of …

Background Induction of labour is carried out for a variety of indications and using a range of
pharmacological, mechanical and other methods. For women at low risk, some methods of …