Radiation therapy induces DNA damage and inflammation leading to fibrosis. Fibrosis can
occur 4 to 12 months after radiation therapy. This process worsens with time and years …

Activation of transcription factor NF-κB is frequently encountered in tumor cells and
contributes to aggressive tumor growth and resistance to chemotherapy and ionizing …

NF-κB, a transcription factor first discovered in 1986, is now known to be closely connected
to the process of tumorogenesis based on a multiplicity of evidence.(1) NF-κB is activated in …

Chronic inflammation has emerged as one of the hallmarks of cancer. Inflammation also
plays a pivotal role in modulating radiation responsiveness of tumors. As discussed in this …

Although radiation therapy (RT) is an integral component of treatment of patients with many
types of cancer, inherent and/or acquired resistance to the cytotoxic effects of RT is …

NADPH oxidases are a major source of superoxide production in the vasculature. The
constitutively active Nox4 subunit, which is selectively upregulated in the lungs of human …

Abstract Docosahexaenoic acid (DHA), a 22: 6 n-3 polyunsaturated fatty acid, is the longest
and most highly unsaturated fatty acid found in most membranes and has been shown to …

Radiation therapy can effectively kill cancer cells through ROS generation. Cancer cells with
upregulated antioxidant systems can develop high radioresistance ability, and the …

There is some evidence to support the toxicity of polyunsaturated fatty acids (PUFAs) and
their oxidative products, suggesting their involvement in the pathogenesis of different …

Aim Polysaccharides were extracted from Rhizoma Dioscoreae Nipponicae to investigate
whether Rhizoma Dioscoreae Nipponicae polysaccharides (RDNP) can act as an …