Proteases form one of the largest and more important groups of enzymes. They selectively
catalyze the hydrolysis of peptide bonds and can be divided into four major classes …

Nb-containing polyoxometalates (POMs) of the Wells− Dawson class inhibit HIV-1 protease
(HIV-1P) by a new mode based on kinetics, binding, and molecular modeling studies …

Most viruses encode their own proteases to carry out viral maturation and these often
require dimerization for activity. Studies on human immunodeficiency virus type 1 (HIV-1) …

Convenient Method for the Preparation of Weinreb Amides via Pd-Catalyzed Aminocarbonylation
of Aryl Bromides at Atmospheric Pressure | Organic Letters ACS ACS Publications C&EN CAS …

Thirty-one N-derivatives of cytisine were prepared in order to modify its pharmacological
profile and to obtain compounds of potential therapeutic interest either at a peripheral or …

The human immunodeficiency virus (HIV) integrase (IN) must covalently join the viral cDNA
into a host chromosome for productive HIV infection. l-Chicoric acid (l-CA) enters cells poorly …

An increasing body of evidence suggests a protective effect of some psychoactive
substances against SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus type 2) …

Suitably protected amino acids were used to investigate the Michael addition of the sulfanyl
group of cysteine, the hydroxyl group of serine and the ε-amino group of lysine to a …

The introduction of side chains bearing epoxide motifs into the molecular scaffold of
kenpaullone and 9-trifluoromethylpaullone led to improved antiproliferative activity of the …

Darunavir, a potent antiviral drug, showed an unusual second binding site on the HIV-1
protease dimer surface of the V32I drug resistant mutant and normal binding in the active …