During the early meiotic prophase, connections are established between chromosomes and
cytoplasmic motors via a nuclear envelope bridge, known as a LINC (linker of …

The regulation of genomic function is in part mediated through the physical organization and
architecture of the nucleus. Disruption to nuclear organization and architecture is …

The nuclear envelope, which protects and organizes the genome, is dismantled during
mitosis. In the Caenorhabditis elegans zygote, nuclear envelope breakdown (NEBD) of the …

Breast cancer susceptibility gene 1 (BRCA1) and binding partner BRCA1-associated RING
domain protein 1 (BARD1) form an essential E3 ubiquitin ligase important for DNA damage …

During the zygotene stage of meiosis, normal progression of chromosome synapsis and
homologous recombination frequently lead to the formation of structural interlocks between …

Vigorous chromosome movement during the extended prophase of the first meiotic division
is conserved in most eukaryotes. The movement is crucial for the faithful segregation of …

Interactions between chromosomes and LINC (linker of nucleoskeleton and cytoskeleton)
complexes in the nuclear envelope (NE) promote homolog pairing and synapsis during …

Life of sexually reproducing organisms starts with the fusion of the haploid egg and sperm
gametes to form the genome of a new diploid organism. Using the newly fertilized …

Meiotic rapid prophase chromosome movements (RPMs) require connections between the
chromosomes and the cytoskeleton, involving SUN (Sad1/UNC-84)-domain-containing …

Interactions between parental chromosomes during the formation of gametes can lead to
entanglements, entrapments and interlocks between unrelated chromosomes. If unresolved …