Alkaloids and isoprenoids modification by copper (I)-catalyzed Huisgen 1, 3-dipolar cycloaddition (click chemistry): toward new functions and molecular architectures
K Kacprzak, I Skiera, M Piasecka, Z Paryzek - Chemical reviews, 2016 - ACS Publications
Despite enormous progress in the field of the synthetic chemistry involving, for example,
catalytic and combinatorial synthesis of a large libraries of compounds, multicomponent …
catalytic and combinatorial synthesis of a large libraries of compounds, multicomponent …
A comprehensive review on steroidal bioconjugates as promising leads in drug discovery
R Bansal, A Suryan - ACS bio & med Chem Au, 2022 - ACS Publications
Ever increasing unmet medical requirements of the human race and the continuous fight for
survival against variety of diseases give birth to novel molecules through research. As …
survival against variety of diseases give birth to novel molecules through research. As …
Bile salts and derivatives: Rigid unconventional amphiphiles as dispersants, carriers and superstructure building blocks
Steroidal surfactants like bile salts have a rigid amphiphilic structure significantly different
from the typical head–tail one. As a result, these molecules show peculiar features in their …
from the typical head–tail one. As a result, these molecules show peculiar features in their …
[HTML][HTML] Steroid-triazole conjugates: A brief overview of synthesis and their application as anticancer agents
Steroids are biomolecules that play pivotal roles in various physiological and drug discovery
processes. Abundant research has been fuelled towards steroid-heterocycles conjugates …
processes. Abundant research has been fuelled towards steroid-heterocycles conjugates …
[HTML][HTML] Synthesis of bi-and bis-1, 2, 3-triazoles by copper-catalyzed Huisgen cycloaddition: A family of valuable products by click chemistry
ZJ Zheng, D Wang, Z Xu, LW Xu - Beilstein journal of organic …, 2015 - beilstein-journals.org
The Cu (I)-catalyzed azide-alkyne cycloaddition reaction, also known as click chemistry, has
become a useful tool for the facile formation of 1, 2, 3-triazoles. Specifically, the utility of this …
become a useful tool for the facile formation of 1, 2, 3-triazoles. Specifically, the utility of this …
A novel [1, 2, 4] triazolo [1, 5-a] pyrimidine-based phenyl-linked steroid dimer: Synthesis and its cytotoxic activity
Abstract A novel [1, 2, 4] triazolo [1, 5-a] pyrimidine-based phenyl-linked steroid dimer was
designed, synthesized and evaluated for its cytotoxic activity against five human cancer cell …
designed, synthesized and evaluated for its cytotoxic activity against five human cancer cell …
Design, synthesis, antimicrobial evaluation and in silico studies of symmetrical bis (urea-1, 2, 3-triazole) hybrids
Abstract In search of 1, 2, 3-triazole-based antimicrobials, some symmetrical bis (urea-1, 2, 3-
triazole) hybrids were synthesized via clicked Huisgen cycloaddition. The structural …
triazole) hybrids were synthesized via clicked Huisgen cycloaddition. The structural …
Design, synthesis and biological evaluation of novel steroidal spiro-oxindoles as potent antiproliferative agents
Two series of novel steroidal spiro-pyrrolidinyl oxindoles 3a–t and 6a–c were designed and
synthesized from dehydroepiandrosterone using the 1, 3-dipolar cycloaddition as the key …
synthesized from dehydroepiandrosterone using the 1, 3-dipolar cycloaddition as the key …
[HTML][HTML] Triazole-based estradiol dimers prepared via CuAAC from 17α-ethinyl estradiol with five-atom linkers causing G2/M arrest and tubulin inhibition
M Jurášek, J Řehulka, L Hrubá, A Ivanová, S Gurská… - Bioorganic …, 2023 - Elsevier
Microtubule dynamic is exceptionally sensitive to modulation by small-molecule ligands. Our
previous work presented the preparation of microtubule-targeting estradiol dimer (ED) with …
previous work presented the preparation of microtubule-targeting estradiol dimer (ED) with …