▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …

The role of neurotrophins as regulatory factors that mediate the differentiation and survival of
neurons has been well described. More recent evidence indicates that neurotrophins may …

▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …

▪ Abstract Neurotrophins are a family of growth factors critical for the development and
functioning of the nervous system. Although originally identified as neuronal survival factors …

Target-derived NGF promotes the phenotypic maintenance of mature dorsal root ganglion
(DRG) nociceptive neurons. Here, we provide in vivo and in vitro evidence for the presence …

Neuronal connections are established and refined through a series of developmental
programs that involve axon and dendrite specification, process growth, target innervation …

A fundamental question in developmental biology is how a limited number of growth factors
and their cognate receptors coordinate the formation of tissues and organs endowed with …

The execution of apoptosis is critical for proper development of the nervous system.
However, it is equally important that neurons strictly inhibit apoptosis after development to …

The target-derived neurotrophic factor" nerve growth factor"(NGF) signals through TrkA to
promote the survival, differentiation, and maintenance of neurons. How the NGF signal in …

Neurons completely transform how they regulate cell death over the course of their lifetimes.
Developing neurons freely activate cell death pathways to fine-tune the number of neurons …