The state of technological advancement to address challenges in the manufacture of rAAV gene therapies

F Destro, W Wu, P Srinivasan, J Joseph, V Bal… - Biotechnology …, 2024 - Elsevier
Current processes for the production of recombinant adeno-associated virus (rAAV) are
inadequate to meet the surging demand for rAAV-based gene therapies. This article reviews …

[HTML][HTML] Constant surface area-to-volume ratio during cell growth as a design principle in mammalian cells

W Wu, AR Lam, K Suarez, GN Smith, SM Duquette… - …, 2024 - pmc.ncbi.nlm.nih.gov
All cells are subject to geometric constraints, such as surface area-to-volume (SA/V) ratio,
that impact cell functions and force biological adaptations. Like the SA/V ratio of a sphere, it …

Direct quantification of sinking velocities across unicellular algae

TP Miettinen, AL Gomez, Y Wu, W Wu, TR Usherwood… - bioRxiv, 2023 - biorxiv.org
Eukaryotic phytoplankton, also known as algae, form the basis of marine food webs and are
responsible for most of marine carbon sequestration when their dead biomass sinks to the …