The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

Cyanine is a class of fluorescent dye with meritorious fluorescence properties and has
motivated numerous researchers to explore its imaging capabilities by miscellaneous …

All living organisms depend on tightly regulated cellular networks to control biological
functions. Proteolysis is an important irreversible post-translational modification that …

Pulsed electron-electron double resonance spectroscopy (PELDOR/DEER) and single-
molecule Förster resonance energy transfer spectroscopy (smFRET) are frequently used to …

Folate receptor (FR) targeting is one of the most promising strategies for the development of
small‐molecule‐based cancer imaging agents considering that the FR is highly …

Near-infrared photoimmunotherapy (NIR-PIT) is a cancer phototherapy that uses antibody-
IR700 conjugate (Ab-IR700) and NIR light. Ab-IR700 forms aggregates on the plasma …

Matrix metalloproteases (MMPs) are the proteolytic enzymes accountable for extracellular
matrix (ECM) modification through their Zn2+-dependent catalytic activity. Among these …

Macrophage elastase [matrix metalloproteinase (MMP)-12] is the most upregulated MMP in
abdominal aortic aneurysm (AAA) and, hence, MMP-12-targeted imaging may predict AAA …

The most exploited strategy to develop potent zinc–metalloprotease inhibitors relies on a
core zinc chelator and a peptidic or nonpeptidic scaffold that provides supplementary …

BMP‐1/tolloid‐like proteinases belong to the astacin family of human metalloproteinases,
together with meprins and ovastacin. They represent promising targets to treat or prevent a …